Making virtual modeling as easy and intuitive as realclay manipulation is still an unsolved problem. This paper takes a step in this direction: in addition to offering standard features such as addition and removal of material, it uses a new real-time plasticity model to let the user apply local and global deformations such as those made in real clay by pressing with a finger or bending a sculp...

The constitutive relation of the quasistatic deformation on two-dimensional packed samples of polygons is calculated using molecular dynamics simulations. The stress values at which the system remains stable are bounded by a failure surface, which shows a power law dependence on the pressure. Below the failure surface, nonlinear elasticity and plastic deformation are obtained, which are evaluat...

The concept of representative crack elements has been successfully introduced to phase-field fracture in previous publications, where anisotropic elasticity [1], visco-elasticity [2], elasto-plasticity and surface friction [3] are considered at small deformations. This framework allows overcome unrealistic predictions for the kinematics, reported e.g. Strobl Seelig [4], Steinke Kaliske [5], kno...

Among diverse factors regulating excitatory synaptic transmission, the abundance of postsynaptic glutamate receptors figures prominently in molecular memory and learning-related synaptic plasticity. To allow for both long-term maintenance of synaptic transmission and acute changes in synaptic strength, the relative rates of glutamate receptor insertion and removal must be tightly regulated. Int...

Activity-dependent gene transcription and protein synthesis underlie many forms of learning-related synaptic plasticity. At excitatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic activity to postsynaptic endocytosis of AMPA-type glutamate receptors. Although the mechanisms for Arc induction have been described, little is known regarding the molecular mac...

Under chronic conditions of neuropathic pain, nociceptive C terminals are lost from their target region in spinal lamina II, leading to reduced thermal hyperalgesia. This region of the spinal cord expresses high levels of polysialic acid (PSA), a cell surface carbohydrate known to weaken cell-cell interactions and promote plasticity. Experimental removal of PSA from the spinal cord exacerbates ...

A selection of surface crack problems is presented to provide insights into Stage I and early Stage II fatigue crack growth. Edge cracks at 45o and 90o to the surface are considered for cracks growing in single crystals. Both single crystal slip and conventional plasticity are employed as constitutive models. Edge cracks at 45o to the surface are considered that either (i) kink in the direction...

This article provides experimental evidence on the pronounced three-dimensional surface effects caused by tension twinning at early stages of plasticity of a magnesium alloy. To achieve this goal, multiscale mechanical testing was combined with strain field, texture and surface morphology quantification. The current investigation correlates crystallography-driven, grain-scale surface roughening...

this talk will introduce the idea that talent development is related to learning where learning is the physiological process of neuro-plastic changes in the brain. to develop talents, individuals must move from novice or beginner’s status to expertise levels of knowledge or skills in a particular domain. learning depends on maximizing an individual’s potential through the experiences he or she ...

This work is devoted to the analysis of elasto-plasticity models arising in soil mechanics. Contrary to the typical models mainly used for metals, it is required here to take into account plastic dilatancy due to the sensitivity of granular materials to hydrostatic pressure. The yield criterion thus depends on the mean stress and the elasticity domain is unbounded and not invariant in the direc...