Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity ...

Background. Scrub typhus may be a life-threatening infection that usually presents as acute undifferentiated febrile illness (AUFI). Because of the similarity of clinical features and absence of sensitive point-of-care testing, however, clinicians have difficulty in differentiating scrub typhus from other etiologies among patients presenting with AUFI in acute healthcare settings. Methods. This...

BACKGROUND Infection-related acute kidney injury (AKI) is an important preventable cause of morbidity and mortality in the tropical region. The prevalence and outcome of kidney involvement, especially AKI, in scrub typhus is not known. We investigated all patients with undiagnosed fever and multisystem involvement for scrub typhus and present the pattern of renal involvement seen. METHODS Fro...

Surgery is considered to have a leading role in the treatment of gastric carcinoma. Surgical supplies are used to cut, divide, and ligate during surgery, and are not only in close contact with normal tissues, but may also be contaminated by pathological tissues and cells. This study sought to determine the presence of exfoliated tumor cells on surgical supplies at different stages during the su...

cal countries but has protean manifestations. The classical presentation of fever with eschar and accompanying gastrointestinal, respiratory or neurological involvement is seen only in a small percentage of cases. Unusual and distracting symptoms and signs have been increasingly associated with scrub typhus, hence, a high index of suspicion should be entertained in febrile children, especially ...

Scrub typhus, also called tsutsugamushi disease in Japan, is one of the most common rickettsial diseases in this country. Fever, skin rash, eschar and elevated hepatic enzymes are main clinical features of scrub typhus. We present the case of a 55 year-old woman contracted with this infection without skin eruption and abnormal liver function. The finding of an unusual eschar helped us to make a...

Background: The Taiwan Area includes the main island of Taiwan and several small associated islands, which are located off the coast of Southern China. The eastern two-thirds of Taiwan’s main island are characterized by rugged mountains covered with tropical and subtropical vegetation. Western Taiwan’s main island is characterized by flat to gently rolling plains. The geographical distribution ...

Dengue fever and scrub typhus are common causes of acute febrile illness of unclear origin in Asia. Though coinfections of many vector-borne diseases have been described, articles on dengue and scrub typhus coinfection are distinctly limited. In case of coinfection with dengue and scrub typhus, vigilant monitoring of vitals, platelets transfusion, and timely treatment with doxycycline are neces...

This is a case report of a 12-year-old returned traveler with typhoid and scrub typhus coinfection. The diagnosis of typhoid was made early with blood cultures and Widal Weil Felix serology. Persistent fever despite appropriate antibiotics for typhoid fever prompted a search for concomitant infection, which led to the diagnosis of scrub typhus confirmed by Orientia tsutsugamushi serology. The p...