Two distinct peroxisomal targeting signals (PTSs), the C-terminal PTS1 and the N-terminal PTS2, are defined. Processing of the PTS2 on protein import is conserved in higher eukaryotes. Recently, candidates for the responsible processing protease were identified from plants (DEG15) and mammals (TYSND1). We demonstrate that plants lacking DEG15 show an expressed phenotype potentially linked to re...

A topological index, which is a number, connected to graph. It often used in chemometrics, biomedicine, and bioinformatics anticipate various physicochemical properties biological activities of compounds. The purpose this article encourage original research focused on graph indices for the drugs azacitidine, decitabine, guadecitabine as well an investigation genesis symmetry actual networks. Sy...

For a given pair of s-dimensional real Laurent polynomials (~a(z),~b(z)), which has a certain type of symmetry and satisfies the dual condition~b(z) T ~a(z) = 1, an s× s Laurent polynomial matrix A(z) (together with its inverse A−1(z)) is called a symmetric Laurent polynomial matrix extension of the dual pair (~a(z),~b(z)) if A(z) has similar symmetry, the inverse A−1(Z) also is a Laurent polyn...

BACKGROUND We analyzed the effects of a docosahexaenoic acid (DHA) supplementation in patients affected with late onset Stargardt disease (STGD). METHODS DHA (840 mg/day) was given to 20 STGD patients for six months. A complete ophthalmologic examination, including best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG), was performed at inclusion day 0 (D0) and at month ...

Mouse oocytes undergo two successive meiotic divisions to generate one large egg with two small polar bodies. The divisions are essential for preserving the maternal resources to support embryonic development. Although previous studies have shown that some small guanosine triphosphatases, such as RAC, RAN, and CDC42, play important roles in cortical polarization and spindle pole anchoring, no o...

This thesis studies the application of geometric concepts and methods in the analysis of strategic-form games, in particular bimatrix games. Our focus is on three geometric concepts: the index, geometric algorithms for the computation of Nash equilibria, and polytopes. The contribution of this thesis consists of three parts. First, we present an algorithm for the computation of the index in deg...

Abstract Let $\varphi _1,\ldots ,\varphi _r\in {\mathbb Z}[z_1,\ldots z_k]$ be integral linear combinations of elementary symmetric polynomials with $\text {deg}(\varphi _j)=k_j\ (1\le j\le r)$ , where $1\le k_1<k_2<\cdots <k_r=k$ . Subject to the condition $k_1+\cdots +k_r\ge \tfrac {1}{2}k(k-~1)+2$ we show that there is a paucity nondiagonal solutions Diophantine system _j({\mathbf x...