We have developed a neuromodulation approach that targets peripheral nerves and utilizes their afferents as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) approach on physiological responses to acute stress induction. TEN was targeted to the ophthalmic and maxillary divisions of the right trigeminal nerve and cervi...

To maintain thermal homeostasis, specific thermogenic tissues are under the control of central thermoregulatory networks that regulate the body's response to thermal challenges. One of these mechanisms involves non-shivering thermogenesis in brown adipose tissue (BAT), which is activated in cold environments in order to defend the body against physical damage as a result of hypothermia. The obj...

It is known that the sudden increases in blood pressure associated with autonomic dysreflexia in people with spinal cord injury (SCI) are due to a spinally mediated reflex activation of sympathetic vasoconstrictor neurons supplying skeletal muscle and the gut. Apart from visceral inputs, such as those originating from a distended bladder, there is a prevailing opinion that autonomic dysreflexia...

INTRODUCTION Systemic malignant diseases cause the induction of autoimmunity, for example, paraneoplastic syndromes. There are no proofs of paraneoplastic syndromes in primary brain tumors. The aim of the study was to evaluate the involvement of the peripheral nervous system, together with an assessment of onconeuronal and antineural antibodies as indicators of humoral immune response against n...

This study investigated associations of early adolescents' (N=190, median age = 12) subjectively experienced emotions and psychophysiological reactions in achievement situations. Self-reported questions assessed emotions. Additionally, autonomic nervous system (ANS) were recorded; skin-conductance response (SCR) heart rate (HR) used to measure sympathetic activity, variability (HRV) was parasym...

OBJECTIVE To determine differences in peripheral and cardiovascular autonomic function between individuals with acute musculoskeletal injury (<1 week) and healthy controls. METHODS Autonomic cardiovascular modulation, baroreceptor sensitivity, skin conductance, and peripheral skin temperature were obtained in 6 subjects with acute musculoskeletal injury and 6 age- and sex-matched controls. Po...

Helwig, Bryan G., Sujatha Parimi, Chanran K. Ganta, Richard Cober, Richard J. Fels, and Michael J. Kenney. Aging alters regulation of visceral sympathetic nerve responses to acute hypothermia. Am J Physiol Regul Integr Comp Physiol 291: R573–R579, 2006. First published February 23, 2006; doi:10.1152/ajpregu.00903.2005.—Hypothermia produced by acute cooling prominently alters sympathetic nerve o...