TO THE EDITOR—We read with great interest the paper of Sousa et al claiming that asymptomatic bacteriuria (ASB) is a risk factor for prosthetic joint infection (PJI) [1]. We congratulate the authors for this important multicenter study [1] and Dr Duncan for the accompanying editorial that highlights the key limitations of the study [2]. The administration of antibiotics for ASB before elective ...

Eighty six children with neuropathic urinary incontinence who had been treated by clean intermittent catheterisation for more than five years were reviewed. Eighty five had congenital lesions, and one traumatic paraplegia. During the day, 72 (84%) patients were dry or had minor stress incontinence only, 11 were damp but controlled with pads, and only three were continuously wet. Eleven abandone...

A gas-chromatographic method for the diagnosis of urinary tract infections caused by Escherichia coli and Klebsiella sp. is described. A total of 96 urine samples from individuals with clinical symptoms of urinary tract infection or pyrexia of unknown origin were tested by conventional and gas-chromatographic methods for bacteriuria. The gas-chromatographic method showed complete agreement with...

Four hundred and seventy-eight pregnant women attending local authority clinics in Portsmouth were screened for bacteriuria using the dip-inoculum transport medium (DITM) spoon method. The detection of asymptomatic bacteriuria in 5% of the patients with a very low proportion of equivocal results (0.83%) suggests that this is an efficient method; and large numbers of urine specimens could be sam...

Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The...

Recently, water diuresis has been shown to promote chronic Escherichia coli bacteriuria following the injection of bacteria into the bladder lumen of rats with normal urinary systems(l). However, maintenance of bacteriuria for periods up to 56 days has not resulted in renal lesions(l,2). Similar effects of water diuresis on bacteriuria have been observed in mice. In this species, however, sever...