objective(s): asthma results from the interaction between genetic and environmental factors. adam33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. materials and methods: this is a case-control study, where four snps s1 (rs3918396), t1 (rs2280091), t2 (rs2280090), v4 (rs2787094) of adam33 gene have been assessed in patients with allergic asthma and normal cont...

the aims of the present study were to propose apolymerase chain reaction-restriction fragment length polymorphismpcr-rflp genotyping method for the ay_376689:c.773c>t single nucleotide polymorphism snp of the equine prkag3 gene, related to muscle performance, as well as to characterize this snp and a second polymorphism, aawr_02017454:g.121684t>c of the spata1 gene, related to male fertility, i...

Vitamin B(12) is an essential micronutrient synthesized by microorganisms. Mammals including humans have evolved ways for transport and absorption of this vitamin. Deficiency of vitamin B(12) (either due to low intake or polymorphism in genes involved in absorption and intracellular transport of this vitamin) has been associated with various complex diseases. Genome-wide association studies hav...

OBJECTIVE Carotid intima-media thickness (cIMT), a marker for atherosclerosis, is affected by smoking and has substantial interindividual variation. We sought to identify the genetic moderators influencing the effect of smoking on cIMT. APPROACH AND RESULTS With a multistage design using 722 379 single nucleotide polymorphisms (SNP), a genome-wide interaction study was performed in a discover...

Micromolar calcium activated neutral protease (CAPN1) was evaluated as a candidate gene for a quantitative trait locus (QTL) on BTA29 affecting meat tenderness by characterization of nucleotide sequence variation in the gene. Single-nucleotide polymorphisms (SNP) were identified by sequencing all 22 exons and 19 of the 21 introns in two sires (Piedmontese x Angus located at the U.S. Meat Animal...

BACKGROUND The serum- and glucocorticoid-regulated kinase (SGK1) gene is an important mediator of aldosterone action, regulating the expression of the renal epithelial Na(+) channel. In renal failure, blood pressure (BP) is markedly salt-dependent and increases with decreasing renal function. Mutations of the SGK1 gene affecting phosphorylation could be responsible for salt-mediated increases i...

Abstract Background LHPP is a tumor suppressor protein associated with various malignancies like liver, oral, pharyngeal, bladder, cervical, and gastric cancers through controlling pathways. Several single nucleotide variants have been reported to cause cancers. The main objectives of our study were investigate the impact deleterious non-synonymous on structure functions protein. Results We use...

BACKGROUND Fentanyl-induced emesis (FIE) is a distressing adverse effect in the postoperative setting. The genetic basis of FIE remains largely unknown, therefore, we examined whether it was associated with specific genetic variants of OPRM1, the gene encoding the main receptor target of fentanyl. METHODS In this prospective case-control study, 193 women undergoing gynaecological surgery unde...

Biological control agents (BCA) are beneficial organisms that are applied to protect plants from pests. Many fungi of the genus Trichoderma are successful BCAs but the underlying mechanisms are not yet fully understood. Trichoderma cf. atroviride strain LU132 is a remarkably effective BCA compared to T. cf. atroviride strain LU140 but these strains were found to be highly similar at the DNA seq...