A 47-year-old man, obese, without medical problems, presented with a 15-day history of painful erythematous nodular lesions on the anterior side lower limbs. He had no improvement antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). developed migratory symmetric arthralgias (ankles, knees, elbows) low-grade fever. The skin progressed to upper On physical examination, mild swelling te...

Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis that is characterized by lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and increased IgG4(+) plasma cells. Serum IgG4 levels usually are elevated. Patients with AIP frequently have disease affecting other organs or sites; these tissues show similar histologic changes, including increased IgG4(+) pla...

In an autoimmune disease, the immune system attacks and harms the body's own tissues. The systemic autoimmune diseases include collagen vascular diseases, the systemic vasculitides, Wegener granulomatosis, and Churg-Strauss syndrome. These disorders can involve any part of the gastrointestinal tract, hepatobiliary system and pancreas. They can cause a variety of gastrointestinal manifestations ...

Background: Dermatoglyphics refers to the study of epidermal ridge patterns of fingers, palms and soles of hand and feet. Fingerprint develops completely at 24th week of embryonic life. Once formed, they are permanent and unalterable throughout the life, not affected by environmental factors. As dermatoglyphic patterns are assumed to be associated with genetic factors, the idea of using it as s...

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Th e hypothesis that type I interferon plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) has gained growing support in recent years [1-4]. Th e early data from the 1970s demonstrating increased functional interferon activity in lupus patient sera have been confi rmed and extended using current technologies that permit detection of the broad gene expression program i...

A muscle biopsy is currently requested to assess the diagnosis of an idiopathic inflammatory myopathy overlapping with a systemic disease. During the past few years, the classification of inflammatory myopathy subtypes has been revisited progressively on the basis of correlations between clinical phenotypes, autoantibodies and histological data. Several syndromic entities are now more clearly d...

Systemic autoimmune diseases (SAD) are a heterogeneous group of immunologically mediated inflammatory disorders including multiorgan involvement. As expected in a multisystem disease, the entire pulmonary system is vulnerable to injury. Any of its compartments may be independently or simultaneously affected. It is difficult to assess the true prevalence of lung disease in cases of SAD. In this ...