Systemic lupus erythematosus is a systemic autoimmune disease that affects the central nervous system, either by direct neuronal damage, injury to brain vessels, or pathogenic mechanisms indirectly induced immune related production and deposition of complexes. The prevalence explicit episodes seizures among SLE patients, varies from 2 8%. In some cases, patients with positivity for antiphosphol...

In 2020 many contributions have been produced on SLE. Our critical digest of the recent literature will be focused genetic factors that contribute to development disease, novel potential therapeutic targets (including IL-23, IL-17, interferons and JAKs), diagnostic prognostic biomarkers, classification criteria, clinical manifestations comorbidities. We then present new treatment options (with ...