Cisplatin represents an important strategy for gastric cancer treatment. However, cisplatin resistance often leads to failure of therapy as well local reoccurrence. Recently, long non-coding ribonucleic acid was demonstrated exert roles in cancer. Expression measured by real time polymerase chain reaction assay cells from different groups. Cell apoptosis checked with Hoechst methods and cell co...

Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitum...

background: some antidepressant drugs can promote neuronal cell proliferation in vitro as well as hippocampal neurogenesis in human and animal models. furthermore, adipose tissue is an available source of adult stem cells with the ability to differentiate in to multiple lineages. therefore, human adipose-derived stem cells (hadscs) may be a suitable source for regenerative medical applications....

The immune reconstitution after allogeneic hematopoietic stem cell transplantation comprises thymus-dependent and thymus-independent pathways. We wanted to improve the understanding of this complex process using two different measurements at definite checkpoints of T-cell neogenesis. We therefore assessed the thymus-dependent pathway by combining measurements of single joint T-cell receptor exc...

background: norepinephrine plays a trophic role in the control of cell replication and differentiation in target cells that express adrenergic receptors. methods: in this study, we have tested the influence of infraphysiological, physiological and supraphysiological concentrations (0.0001 nm, 1 nm, 10000 nm) of human norepinephrine on the proliferation of breast cancer cells (human breast adeno...

objective: the development of combining mesenchymal stem cells (mscs) with surface modified three-dimensional (3d) biomaterial scaffold provides a desirable alternative for replacement of damaged and diseased tissue. nanofibrous scaffolds serve as suitable environment for cell attachment and proliferation due to their similarity to the physical dimension of the natural extracellular matrix. in ...

Through positive and negative selection, the thymus allows a small fraction of immature CD4 ϩ 8 ϩ double positive thymocytes to differentiate into mature CD4 ϩ 8 Ϫ or CD4 Ϫ 8 ϩ single positive cells; these cells are released into the periphery to establish the mature T cell pool. Positive selection rescues thymocytes that express TCR with low affinity for peptides bound to MHC molecules express...

Aim Evaluation of the in vitro immunomodulatory potential of Artemisia indica Willd. methanolic extract in chicken lymphocyte culture system through lymphocyte (B and T cells) proliferation assay, after standardizing the maximum non-cytotoxic dose (MNCD) in chicken lymphocytes. Materials and Methods Fresh aerial parts of A. indica Willd. (family: Asteraceae) specimens were collected (altitude...