Ethnopharmacological relevance: Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) is a medicinal plant known for its anxiolytic, antidepressant and anticonvulsant activities in Cameroonian folk medicine. Aim of the study: The aim this work to evaluate anxiolytic effects aqueous extracts investigate mechanism action. Materials methods: Elevated plus maze test open field were u...

Among all voltage-gated calcium channels, the T-type Ca²⁺ channels encoded by the Ca(v)3.2 genes are highly expressed in the hippocampus, which is associated with contextual, temporal and spatial learning and memory. However, the specific involvement of the Ca(v)3.2 T-type Ca²⁺ channel in these hippocampus-dependent types of learning and memory remains unclear. To investigate the functional rol...

Habits tend to form slowly but, once formed, can have great stability. We probed these temporal characteristics of habitual behaviors by intervening optogenetically in forebrain habit circuits as rats performed well-ingrained habitual runs in a T-maze. We trained rats to perform a maze habit, confirmed the habitual behavior by devaluation tests, and then, during the maze runs (ca. 3 s), we disr...

ABSTRACT. Investigation of the association between physical frailty and cognitive performance through spatial navigation is important to enable identification individuals with impairment comorbidity. Objective: To analyze in frail pre-frail institutionalized older adults. Methods: Forty people both sexes, aged 60 years or over, residing four Brazilian Long-Term Care Facilities (LTCFs) participa...

Under the conditions of double choice in a Y-maze, proportion of flies gathering in its arm depended on its relative illumination, approximately so that (1) at, or below the lower critical relative intensity limit, it assumed a constant minimum value; (2) at, or above the species-specific upper critical limit, the proportion of choice assumed a constant maximum value; whereas (3) between these ...

The activity of hippocampal pyramidal cells reflects both the current position of the animal and information related to its current behavior. Here we investigated whether single hippocampal neurons can encode several independent features defining trials during a memory task. We also tested whether task-related information is represented by partial remapping of the place cell population or, inst...