Globally, the number of people with Type 2 diabetes (T2D) or diabetes mellitus is projected to grow to 366–440 million by 2030, with three quarters of the increase in lowto middle-income countries [1]. The burden of communicable diseases is concentrated in low-income and resource-strapped regions, and one could predict that diabetes-related infections will rise significantly in these areas. Giv...

background: considering the effect of socioeconomic factors on the appearance of chronic diseases, and also the importance of this issue for policy makers of health care services, we tried to assess the role socioeconomic factors have in diabetes complications. this survey may have some benefits in prevention and control of diabetes.   methods: this cross-sectional study was conducted on 384 di...

MicroRNAs (miRNAs) are small non-coding RNAs that function as crucial regulators of gene expression. Recently, dysregulation of miRNA expression in the blood has been demonstrated to be associated with various diseases, including type 2 diabetes mellitus (T2D), suggesting a potential for their use as biomarkers of disease prognosis. The present study examined the expression levels of T2D‑associ...

ObjectiveTo determine the prevalence rate and associated risk factors for each stage of Dysglycemia-Based Chronic Disease (DBCD) model, which 4 distinct stages prompts early prevention to avert Diabetes cardiometabolic complications.MethodsSubjects between 25 64 years old from a random population-based sample were evaluated in Czechia 2013 2014 using cross-sectional design. DBCD were: 1 “insuli...

OBJECTIVE To examine the collective effects of type 1 (T1D) and type 2 diabetes (T2D) risk alleles on prostate cancer (PCa) risk. METHODS Using data on 14 and 18 single nucleotide polymorphisms (SNPs) that effect T1D and T2D risk, respectively, we generated risk scores (a 'risk allele count' and a 'genetic relative risk') for both T1D and T2D for 1,171 non-Hispanic white, PSA-screened PCa cas...

CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of about 50% of all marketed drugs. Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect CYP3A activity. Evidences suggest that drug disposition is altered in type 1 (T1D) and type 2 diabetes (T2D). The objective was to evaluate the effect...

Objective To estimate age-specific and sex-specific all-cause mortality among adults with and without type 2 diabetes (T2D) in Germany. Research design and methods The German National Health Interview and Examination Survey 1998 (GNHIES98) included a mortality follow-up (median follow-up time 12.0 years) of its nationwide sample representative of the population aged 18-79 years. After exclusi...

G protein–coupled receptors (GPCRs) are important drug targets in type 2 diabetes (T2D). GPCR gene variants can modify the responsiveness to drugs and be a risk factor for T2D development associated traits. genes of interest this respect GIPR, GLP1R, MC4R, MTNR1B. Once association with or altered response established, consequences on receptor function have determined. Depending nature function,...

OBJECTIVE To characterize dropouts from type-2 diabetes (T2D) care in communal primary health care. DESIGN An observational study. SETTING In a Finnish city, patients with T2D who had not contacted the public primary health care system during the past 12 months were identified with a computer based search and contacted by a trained diabetes nurse. SUBJECTS Dropouts from T2D treatment. M...

Once referred to as adult-onset diabetes, type 2 diabetes (T2D) has emerged in youth as a consequence of the worldwide increase in obesity. The development of T2D among young individuals has significant public health consequences as these youth are likely to manifest the complications of diabetes, including retinopathy, nephropathy, neuropathy, and cardiovascular disease, at a time that should ...