A 63-year-old Japanese woman with advanced lung adenocarcinoma developed isolated adrenocorticotropin deficiency caused by immune checkpoint inhibitor (ICI)-related hypophysitis following 8 months of nivolumab therapy. Prompt corticosteroid replacement therapy effectively relieved her secondary adrenal insufficiency symptoms and allowed her to pursue nivolumab therapy, which had been effective ...

in order to increase grain yield, nitrogen use efficiency (nue) and nitrogen apparent recovery fraction (narf) in wheat (triticum aestivum l.), this experiment was carried out with 5 or 6 treatments and 3 or 4 replications in 14 locations at 22 different sites in iran during the 2004-05 growing season. the experiment was designed as a completely randomized block. the effect of n sources and tim...

The aim of this work was to study the biodegradation of different types of automotive lubricant oils adapted to the aqueous medium using a base inoculum and an aqueous inoculum. Four treatments were carried out in two consecutive and similar experiments: T1 (control); T2 (half-synthetic oil); T3 (mineral oil); T4 (used oil). The results showed the following decreasing order of CO2 production in...

The primary associations of the HLA class II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1D) are well established. However, the role of polymorphism at the HLA-DRB3, HLA-DRB4, and HLA-DRB5 loci remains unclear. In two separate studies, one of 500 subjects and 500 control subjects and one of 366 DRB1*03:01-positive samples from selected multiplex ...

On October 13, 2006, President George W. Bush signed the Unlawful Internet GamblingEnforcementAct (UIGEA)of2006asanattachment to theSecurity andAccountability for Every Port Act of 2006. UIGEA is the first federal regulation specific to the online gaming industry. In this article, we examine the impact of UIGEA and its subsequent interpretation (through administrative rulemaking andDepartment o...

Thirty-two Suffolk wether lambs were fed for 84 d in a 2 x 2 factorial experiment using two levels of dietary protein (9.0 to 12.1% CP, low protein, LP; or 12.8 to 14.4% CP, high protein, HP) and supplemental Cr (none, C; or 400 ppb Cr as chromium tripicolinate, Cr). At 14- to 21-d intervals, lambs were weighed, and jugular blood samples were collected. Mean ADG and carcass weight (P > .10) did...

Abstract AA7075-T6 aluminum alloy samples were shot peened at various peening pressures in the range of 10–70 psi to study their mechanical and tribological properties under dry mineral oil lubrication conditions. The surface roughness apparently increased with pressure. best bearing was obtained when process carried out highest pressure 70 psi. It found that hardness decreased wear samples. te...

OBJECTIVE To evaluate the efficacy of donepezil in patients with early-stage Alzheimer disease. DESIGN Multicenter, randomized, double-blind, 24-week, placebo-controlled study that enrolled patients with early-stage Alzheimer disease. Patients were randomized in an approximately 2:1 ratio to donepezil, 5 mg/d, for the first 6 weeks, with a forced escalation to 10 mg/d thereafter (n = 96), or ...