نتایج جستجو برای: tap1
تعداد نتایج: 418 فیلتر نتایج به سال:
Adaptive penalty function methods (APFMs) are promising constraints handling techniques. In an APFM, a parameter which balances constrains’ violations and objective values is adaptively adjusted. This work modifies APFM that uses near feasibility threshold (NFT), portion around the feasible region where infeasible solutions considered as good ones, for constrained multiobjective optimization. T...
To localize the MHC-linked diabetogenic genes in the nonobese diabetic (NOD) mouse, a recombinational hotspot from the B10.A(R209) mouse was introduced to the region between the MHC class I K and class II A of the NOD mouse with the recombinational site centromeric to the Lmp2/Tap1 complex by breeding the two strains. Replacement of the NOD region centromeric to the recombinational site with th...
Antigen presenting cells (APCs) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8(+) T cells, both in vitro and in vivo. Compared with controls, immunization of YOD1-C160S mice led to greater expansion of specific CD8(+) T cells and showed improved control of infection with a recombinant -herpes virus, MHV-68...
Peptides presented by major histocompatibility complex (MHC) class I rnolecnles are derived from intracellularly synthesized proteins. Cytosolic proteins are fragmented into peptides, which are subsequently transported via the transporter of antigen presentation (TAP) into the endoplasmic reticttlum (ER), where they bind to MHC class I molecules. We have investigated the requirements for MHC cl...
MHC class I and class II are crucial for the adaptive immune system. Although regulation of MHC class II expression by CIITA has long been recognized, the mechanism of MHC class I transactivation has been largely unknown until the recent discovery of NLRC5/class I transactivator. In this study, we show using Nlrc5-deficient mice that NLRC5 is required for both constitutive and inducible MHC cla...
Data was searched against a Swiss-Prot® complete human database with a 1% FDR criteria using Percolator. Analysis and interpretation of DIA data were performed using Biognosys Spectronaut 7. A library was built from the combined search outputs of Proteome Discoverer 1.4 using a high confidence peptide filter and fragment filter settings of 300 to 1800 m/z with fragments greater than y3 or b3. M...
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