We have devised a novel amplification strategy based on isothermal strand-displacement polymerization reaction, which was termed multiple cross displacement amplification (MCDA). The approach employed a set of ten specially designed primers spanning ten distinct regions of target sequence and was preceded at a constant temperature (61-65 °C). At the assay temperature, the double-stranded DNAs w...

When observers are asked to localize the final position of a moving target, the judged position is usually displaced from the actual position in the direction of motion. The short-term time course of the displacement was investigated to test theories that attribute the localization error to spatial and temporal properties of human perception or to representational momentum. It was found that br...

introduction: it has been shown that joint click, an initial and common finding in internal derangement (id), respond to neither conservative treatment nor surgical intervention. this raises the question as to whether it must be treated in the absence of other pertinent signs and symptoms, so the aim of this study was to investigate and compare the mri findings of tmj in both normal subjects an...

abstract for seismic design, it is important to estimate the, maximum lateral displacement (inelastic displacement) of the structures due to earthquakes for several reasons. seismic design provisions estimate the maximum roof and storey drifts occurring in major earthquakes by amplifying the roof displacement and drifts of the structures obtained by elastic analysis subjected to seismic design ...

Extraretinal information, such as corollary discharge (CD), is hypothesized to help compensate for saccade-induced visual input disruptions. However, support for this hypothesis is largely for one-dimensional transsaccadic visual changes, with little comprehensive information on the spatial characteristics. Here we systematically mapped the two-dimensional extent of this compensation by quantif...

BACKGROUND Receptor occupancy (RO) assays provide a means to measure the direct interaction of therapeutics with their cell surface targets. Free receptor assays quantify cell-surface receptors not bound by a therapeutic while total receptor assays quantify the amount of target on the cell surface. METHODS We developed both a flow cytometry-based free RO assay to detect free surface CXCR4, an...

The nonlinear dynamic characteristic of a tubular linear eddy current damper (TLECD) and the transient responses to shock excitations single-degree-of-freedom (SDOF) system with TLECD are studied. First, force-velocity relationship is discussed using finite element simulation mathematical model fitting. Next, influences three forms excitation various mechanical parameters on vibration control a...

Online control of movement requires complex integration of predictive central feedforward and peripheral sensory feedback signals. We studied the hand trajectories of human subjects pointing to visual targets that abruptly changed locations by different amounts and modeled the mechanism of rapid online correction using a dynamic model of a two-joint limb. Small unperceived and large detected ta...

Effects of cross-modal information on representational momentum and on representational gravity (ie on displacement of remembered location in the direction of target motion or in the direction of gravitational attraction, respectively) were examined. In experiment 1, ascending or descending visual motion (in the picture plane) was paired with ascending or descending auditory motion (in frequenc...

Acoustic radiation force has been proposed as a method of interrogating the mechanical properties of tissue. One simple approach applies a series of focused ultrasonic pulses to generate an acoustic radiation force, then processes the echoes returned from these pulses to estimate the radiation-force-induced displacement as a function of time. This process can be repeated at a number of location...