vaccination has greatly improved human health. despite of all improvements in this field, there is not an efficient vaccine for many diseases, and of the available ones, some could not produce a long-term immunity. recently, there have been many researches on the applicability of nanostructures as an efficient system for vaccine delivery, and the initial results have been promising. their poten...

In previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1 shRNA vector were loaded into the co-delivery system, and in vitro DOX thermosensitive release a...

objective(s): pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. researchers have intended to reformulate drugs so that they may be more safely used in human body. the more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. the aim of t...

the use of magnetic fields in targeted drug delivery, especially for treatment of cancers and tumoral regions, is one of the significant techniques in the field of modern methods of treatment. considering that many vital biological tissues have been located deep in the body, then for targeted drug delivery and effective treatment in these tissues, it is required to bring therapeutic agent to th...

Focused ultrasound in conjunction with lipid microbubbles has fully demonstrated its ability to induce non-invasive, transient, and reversible blood-brain barrier opening. This study was aimed at testing the feasibility of our lipid-coated microbubbles as a vector for targeted drug delivery in the treatment of central nervous system diseases. These microbubbles were labeled with the fluorophore...

Targeted Protein Deliveries In article number 2204620, Hak-Sung Kim and co-workers develop a new type of protein self-assembly using human clathrin for targeted delivery. A redesigned triskelion is dual-functionalized with functional biomolecules. The resulting assembly exhibits significantly high avidity an efficient delivery cargo into tumor cells.

Due to the ability of the blood-brain barrier (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood-brain tumor barrier (BBTB), and nose-to-b...

first principles calculations were carried out for investigation the novel 7-hydroxycoumarinyl gallates derivatives in gas and liquid phases using density functional theory (dft) method. computational chemistry simulations were carried out to compare calculated quantum chemical parameters for gallates derivatives. all calculations were performed using dmol3 code which is based on dft. the doubl...

in this study, poly(ethylene-co-vinyl alcohol) (evoh) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get evohs and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 da) succinate (pegs) along with targeting with retinoic acid (ra) to get final modified active and passive targeted conjugate (pegs-evohs-ra) to evaluate ...