introduction evaluation of the delivered dose of externally wedged photon beams by external diode dosimeters during the treatment process requires the estimation of exit surface dose correction factors in various wedge angles and field sizes. materials and methods a system of absorbed dose evaluation, using p-type diode dosimeters placed on the exit surface of a phantom, was characterized for e...

esophageal cancer is one of the most common malignancies with a growing occurrence . it presently ranks ninth among the most frequent cancers in the world and the sixth leading cause of death from cancer . for a variety of reasons, the mainstream of patients with esophageal cancer is actually not suitable for esophagectomy. more than 50% have locally advanced unresectable or metastatic tumors a...

introduction intensity modulated radiation therapy (imrt) has made a significant progress in radiation therapy centers in recent years. in this method, each radiation beam is divided into many subfields that create a field with a modulated intensity. considering the complexity of this method, the quality control for imrt is a topic of interest for researchers. this article is about the various ...

background: intra-operative radiation therapy (iort) is the transfer of a single large radiation dose to the tumor bed during surgery with the final goal of improving regional tumor control. this study aimed to investigate the safety, effectiveness and economic evaluation of intra-operative radiation therapy.   methods : the scientific literature was searched in the main biomedical databases (c...

We have demonstrated that radiation alone is weakly effective at generating anti-tumor adaptive immune responses despite release of tumor-associated antigen. We hypothesized that providing potent adjuvant would improve this immune response increasing immune control of local and distant disease. Recently, we have shown that activation of STimulator of INterferon Genes (STING) innate signaling ha...

Monoclonal antibodies binding the epidermal growth factor receptor (EGFR), such as cetuximab or panitumumab, are widely used targeted therapeutics for the treatment of patients with colorectal cancer. The clinical significance of these drugs has so far been associated with combined chemotherapy or radiation. It has been shown that these treatment strategies have their clinical limitations and d...

Glioblastoma multiforme (GBM) are extremely aggressive brain tumors characterized by resistance to standard treatment modalities including surgery, radiation therapy and chemotherapy. While radiation therapy is the standard treatment after surgical resection, these tumors invariably recur and are associated with a uniformly dismal prognosis. Cytotoxic chemotherapy has failed to improve on the m...

Glioblastoma is most common and most aggressive cancer of brain. for treatment surgery is first selection and radiation therapy then chemotherapy. The median survival of Patients with GBM is less than a year after diagnosis. Glioblastoma is basically resistant to common cancer treatments. today to improve the response of patients to treatment, a number of strategies such as the use of radiation...

Although it is a pillar of cancer care, radiation therapy historically has had curative potential for minority patients and achieved cure in even fewer. Over the last few decades however, advances with concomitant systemic therapies have led to improved survival expanding indications. Definitive become standard care locally advanced lung selected early-stage cancer. New paradigms are now emergi...