Conventional clock and data recovery (CDR) using a phase locked loop (PLL) suffers from problems such as long lock time, low frequency acquisition and harmonic locking. Consequently, a CDR system using a time to digital converter (TDC) is proposed. The CDR consists of simple arithmetic calculation and a TDC, allowing a fully digital realization. In addition, utilizing a TDC also allows the CDR ...

This brief proposes a new adaptive-robust formulation for time-delay control (TDC) under less-restrictive stability condition. TDC relies on estimating the unknown system dynamics via artificial introduction of time delay, often referred to as estimation (TDE). In conventional TDC, error, called TDE is taken be upper bounded by constant assumption small delay and, most importantly, priori state...

Previous studies applying automatic preprocessing methods on Structural Magnetic Resonance Imaging (sMRI) report inconsistent neuroanatomical abnormalities in Autism Spectrum Disorder (ASD). In this study we investigate inter-method differences as a possible cause behind these inconsistent findings. In particular, we focus on the estimation of the following brain volumes: gray matter (GM), whit...

Catharanthus roseus produces a large array of terpenoid indole alkaloids (TIAs) that are an important source of natural or semisynthetic anticancer drugs. The biosynthesis of TIAs is tissue specific and induced by certain phytohormones and fungal elicitors, indicating the involvement of a complex transcriptional control network. However, the transcriptional regulation of the TIA pathway is poor...

A data driven multi-channel Time-to-Digital Converter (TDC) circuit with programmable resolution (~25ps – 800ps binning) and a dynamic range of 102.4μs has been implemented in a 0.25μm CMOS technology. An on-chip PLL is used for clock multiplication up to 320MHz from an external 40MHz reference. A 32 element Delay Locked Loop (DLL) performs time interpolation down to 97.5ps. Finally, finer time...

The species Enterococcus faecalis is able to catabolise the amino acid tyrosine into the biogenic amine tyramine by the tyrosine decarboxilase (TDC) pathway Ladero et al. (2012) [1]. The TDC cluster comprises four genes: tyrS, an aminoacyl-tRNA synthetase-like gene; tdcA, which encodes the tyrosine decarboxylase; tyrP, a tyrosine/tyramine exchanger gene and nhaC-2, which encodes an Na(+)/H(+) a...

Tyrosine decarboxylase (TDC, EC 4.1.1.25) is an enzyme that catalyzes the decarboxylation of l-tyrosine to produce tyramine and CO2. In this study, a 1881-bp tdc gene from Lactobacillus brevis was cloned and heterologously expressed in Escherichia coli BL21 (DE3). Glucose was discovered to play an important role in the soluble expression of rLbTDC. After optimization, recombinant TDC (rLbTDC) w...

The purpose of this project is to develop methods to analyze human communication using the temporal data crystallization (TDC). We studied following four subjects. At first, we developed a method of meta-level discussion analysis. This method increases precision of TDC analysis by comparing the result of the target record to those of other records. We showed the usefulness of this method by app...

The present study investigates intraindividual variability (IIV) in the Color-Stroop test and in a simple reaction time (SRT) task. Performance level and variability in reaction times (RTs)-quantified with different measures such as individual standard deviation (ISD) and coefficient of variation (ICV), as well as ex-Gaussian parameters (mu, sigma, tau)-were analyzed in 24 children with attenti...

Children with unilateral cerebral palsy (CP) have been shown to improve their motor performance with sufficient practice. However, little is known about how they learn goal-oriented tasks. In the current study, 21 children with unilateral CP (age 4-10 years old) and 21 age-matched typically developed children (TDC) practiced a simple bimanual speed stack task over 15 days of practice. Both grou...