Introduction Depression shows a moderate heritability of 37-42%, which can be up to 75% in severely depressed samples 75%. At the same time SNP-based depression GWAS-s is around 8-9%. Heterogeneity depressive phenotype may contribute not only lack understanding its genetic background but also hinder identification novel targets. Thus clinically relevant intermediate endophenotypes are needed fo...

OBJECTIVES The purpose of this study was to investigate the psychological characteristics of the Sasang constitutions by using Braverman nature assessment (BNA). METHODS One hundred seventy-four students participated in this study, and among them, the 142 individuals who had clearly identified Sasang constitutional types were used for the analysis. Sasang constitutions and the Braverman tempe...

BACKGROUND Although relations between depressive and narcissistic pathologies have been proposed in both psychoanalytic and phenomenological literatures, empirical research generally fails to confirm this link. Common measures of narcissism, however, emphasize grandiose rather than vulnerable traits, and include both adaptive and maladaptive features. We therefore assessed the relation between ...

In the conclusion to first book of Treatise, Hume’s skeptical reflections have plunged him into melancholy. He then proceeds through a complex series stages, resulting in renewed interest philosophy. Interpreters struggled explain connection between stages. I argue that repeated invocation four humors ancient and medieval medicine explains succession, sheds new light on significance skepticism....

Temperament and personality traits such as neuroticism and behavioral inhibition are prospective predictors of the onset of depression and anxiety disorders. Exposure to stress is also linked to the development of these disorders, and neuroticism and inhibition may confer or reflect sensitivity to stressors. Several lines of research have documented hyperactivity of the hypothalamic-pituitary-a...

Animals are known to exhibit different temperaments when living in human proximity. Eastern chipmunks (Tamias striatus) specifically behave more boldly and are more docile when their territories are in proximity to human structures. Differences in behavior across a gradient of human disturbance can indicate underlying differences in personality across the gradient. Changes in average personalit...

BACKGROUND Affective temperaments (anxious, depressive, cyclothymic, irritable and hyperthymic) measure subclinical manifestations of major mood disorders. Furthermore, cumulating evidence suggests their involvement in somatic disorders as well. We aimed to assess associations between affective temperament scores and blood pressure and arterial stiffness parameters in hypertensive patients. M...