C.RF- Tshr(hyt/hyt) mice have a mutated thyroid-stimulating hormone receptor (TSHR), and, without thyroid hormone supplementation, these mice develop severe hypothyroidism. When hypothyroid Tshr(hyt/hyt) mice were exposed to cold (4 degrees C), rectal temperature rapidly dropped to 23.9 +/- 0.40 degrees C at 90 min, whereas the wild-type mice temperatures were 37.0 +/- 0.15 degrees C. When we c...

Thyroid glands from different species contain two forms of CAMP-dependent protein kinases (type I, type II), which differ in their sensitivity to the TSH stimulation. Modifications of the type II enzyme are much more rapid and more important than those of the type I, both in the presence of excess, or in the absence of TSH [ 1,2]. The higher sensitivity of the type II kinase to hormonal action ...

We compared four sensitive procedures for thyrotropin (TSH)--Corning's Magic-Lite, ElectroNucleonics' Delfia, Baxter's Stratus, Nichols' Allegro--for their ability to completely discriminate TSH concentrations in sera in euthyroidism, hyperthyroidism, and hypothyroidism. We evaluated the analytical and clinical performance of these procedures according to previously published criteria. All proc...

Nghiên cứu này được thực hiện nhằm đánh giá sự khác nhau về đặc điểm hóa lý bao gồm pH, độ dẫn điện (EC), khả năng trao đổi cation (CEC) và hàm lượng carbon của than sinh học (TSH) từ vỏ sầu riêng (VSR) mít (VM). Trong cùng điều kiện nhiệt phân, EC, CEC hai loại TSH là nhau. Kết quả cho thấy VSR (85%) có ẩm cao hơn VM (81,7%). Hiệu suất tạo thu lần lượt 39% 39,7%. Than (TSH-VSR) trị pH EC thấp ...

We examined the relative effects of thyrotropin (TSH) and TSH receptor autoantibodies in the sera of patients with autoimmune thyroid disease on three TSH-lutropin/chorionic gonadotropin (LH/CG) receptor extracellular domain chimeras. Each chimera binds TSH with high affinity. Only the chimera with TSH receptor extracellular domains ABC (amino acids 1-260) had a functional (cAMP) response to th...

background: it is widely recognized that neuromuscular function is temperature sensitive. changes in muscle temperature may affect muscle force development. the aim of this study was to investigate the effects of temperature on wrist flexor muscles endurance. methods: fifteen healthy subjects (mean age  21.13 ±1.30 years) participated in the present study.  the wrist flexor muscles endurance wa...

objective: influenza virus a (h1n1) is an important subtype of the influenza respiratory viruses, which has important worldwide implications. hemagglutinin (ha), an important viral antigen, is responsible for binding to human cell receptors leading to an onset of the disease process. considering the critical role of viral attachment, this study focuses on the extraction and cloning of ha and it...

To our knowledge, we have developed a novel temperature-jump optical tweezers setup that changes the temperature locally and rapidly. It uses a heating laser with a wavelength that is highly absorbed by water so it can cover a broad range of temperatures. This instrument can record several force-distance curves for one individual molecule at various temperatures with good thermal and mechanical...