The development of form and morphology of cartilage in limbs from control and retinoic acid-treated DBA/2J mice were studied in organ culture. Somite number at explantation (SE) ranged from 29 to 56. All cartilage segments except digits developed in cultures of 29somite control limb-buds; digits developed well only from limb-buds of SE45 and older stages. Maternal treatment with retinoic acid s...

A number of plant toxins have been shown to be teratogenic to livestock. The teratogenic action of some of these alkaloids is mediated by nicotinic acetylcholine receptors (nAChR). However, for many of these alkaloids it is difficult to obtain sufficient quantities of individual alkaloids to perform teratology studies in livestock species. Therefore the objective of this study was to determine ...

This review outlines briefly the history and present status of the problem of carcinogenic, teratogenic and mutagenic effects of arsenic. Discrepancies between clinical observations and positive results of epidemiological studies and the experimental induction of cancer by arsenic are discussed. The present knowledge of the mechanism of teratogenic and mutagenic effects of arsenic is analyzed. ...