Cleavage of the C-N bond of carboxamides generally requires harsh conditions. This study reveals that tris(amido)Al(III) catalysts, such as Al2(NMe2)6, promote facile equilibrium-controlled transamidation of tertiary carboxamides with secondary amines. The mechanism of these reactions was investigated by kinetic, spectroscopic, and density functional theory (DFT) computational methods. The cata...

Superphanes, compounds in which the two benzene rings clamped parallel on top of each other by six bridges, have been attracting considerable interest because their structural beauty and symmetry. However, progress research superphane chemistry beyond has seriously hampered poor availability. Herein, we report facile scalable synthesis a collection superphanes with diversity unique photophysica...

In the present work, vinyl benzyl chloride (VBC) was polymerized by using free radical polymerization. The obtained PVBC reacted with dibutyl amine to obtain tertiary modified polystyrene based polymer (PVBC-Dibutyl amine). inverse gas chromatography (IGC) method used examine thermodynamic properties of polymer. Firstly, retention diagrams some polar and non-polar solvents on PVBC-Dibutyl were ...

Two vanillin-hydrazone compounds as the colorimetric amine detection during chicken meat spoilage are described. hydrazone (1 and 2) have been synthesized from condensation reaction of vanillin with phenylhydrazine 2,4-dinitrophenylhydrazine. Their properties for recognition were determined by naked eye UV-vis spectra. indicators investigated toward primary amine: butylamine (BA); secondary dim...

The rates of reaction with nitrous acid of four methylsubstituted piperidines to form the corresponding Nnitrosopiperidines were compared with that of piperidine. The relative rates for piperidine, 2-methyl-, 2,6-dimethyl-, and 2,2,6,6-tetramethyl-piperidine were approximately 100:20:10:1, showing considerable steric hindrance tp nitrosation by the «methyl groups. The rate of formation of nitr...

This article describes the synthesis of a library of structurally diverse bifunctional organocatalysts bearing both a quasi-Lewis acidic (thio)urea moiety and a Brønsted basic tertiary amine group. Sequential modification of the modular catalyst structure and subsequent screening of the compounds in the alcoholytic dynamic kinetic resolution (DKR) of azlactones revealed valuable structure-activ...

The side effects of physostigmine, a tertiary amine anticholinesterase agent commonly used to treat postanaesthetic depression caused by a large number of drugs, are thought to be fairly mild. A case is reported in which atrial fibrillation followed a total dose of 2 mg of this drug to a patient who was slow in recovering from a general anaesthetic. The arrhythmia was self-limiting and required...

A new and efficient synthetic method to obtain fully-substituted hexahydroisoindolinones was developed by using bifunctional tertiary amine-thioureas as powerful catalysts. As far as we know, there is no efficient synthetic method developed toward fully-substituted hexahydroisoindolinones. The products were obtained in good yield and diastereoselectivity. The one-pot cascade quadruple protocol ...

A one-pot, convenient method for the preparation of optically active homoallylic alcohols from allyl halides was developed. Allyltrichlorosilanes were generated in situ from allyl halides and trichlorosilane in the presence of cuprous chloride and tertiary amine. Without isolation of the allyltrichlorosilanes, benzaldehyde and chiral biquinoline N,N'-dioxide were introduced into the same flask,...

Aliphatic cyclic tertiary amines constitute a major class of naturally occurring and synthetic drugs directed at central biogenic amine receptors. Microsomal metabolism of these amines is known to be associated with low levels of covalent binding and/or suicide inactivation of the pertinent metabolizing P-450 isozymes; two of the more notorious examples are phencyclidine (1-(1phenylcyclohexyl)p...