• Limit dose test – this is the preferred test when toxicity is expected to be low and lethality is unlikely at the limit dose. The limit dose must be adequate for assessment purposes, and it is usually 2000 mg/kg body-weight. • Full test: LD50-only test – this is the preferred test when an estimate of the median lethal dose is required but neither the slope of the dose response curve or the co...

genetic parameters were estimated for somatic cell score (scs) in dairy cattle of iran using test day records. the records of first lactation were extracted from the database of national animal breeding center for cows calved between 2001 and 2010. data included 222923 test-day records, obtained from 29668 animals distributed in 100 different herds. estimates were carried out through gibbs samp...

This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies...

Tensile stress-strain curve is of high importance in mechanics of materials particularly in numerical simulations of material deformations. The curve is usually obtained by experiment but is limited by necking phenomenon. Engineering stress-strain curve is converted to true stress-strain curve through simple formulas. The conversion, however, is correct up the point of necking. From this point ...

According to the direct homogenization theory of inhomogeneous material, a single medium homogenization constitutive model of the confined concrete in the steel box-concrete combined member has been established, and model parameters have been determined by the measured data of the bending test. By analyzing the theoretical ultimate strength and overall process curve, the results obtained is con...

In diagnostic test studies, one crucial task is to evaluate the diagnostic accuracy of a test. Currently, most studies focus on the Receiver Operating Characteristics Curve and the Area Under the Curve. On the other hand, the Youden index, widely applied in practice, is another comprehensive measurement for the performance of a diagnostic test. For a continuous-scale test classifying diseased a...