Klinefelter syndrome (KS) is a hypergonadotropic hypogonadism characterized by a 47, XXY karyotype. The risk of testicular cancer in KS is of interest in relation to theories about testicular cancer etiology generally; nevertheless it seems to be low. We evaluated the need for imaging and serum tumor markers for testicular cancer screening in KS. Participants were 40 consecutive KS patients, en...

OBJECTIVE To evaluate the impact on testicular function of the surgical approach used to treat testicular torsion. PATIENTS AND METHODS Seventeen males operated on for testicular torsion at a median age of 14 years were investigated. Serum follicle-stimulating hormone (FSH), testosterone and inhibin B as well as testicular volume were measured early (median 36 days) and/or late (median 1.1 ye...

OBJECTIVE To examine effects of nondescent of normal testis and of various orchidopexy techniques on antisperm antibody (ASA) production and histologic testicular lesions. DESIGN Experimental cohort study. SETTING Laboratories of surgical research and biology of reproduction, academic medical centers. PATIENT(S) Lewis rats, immature and adult. INTERVENTION(S) Eighteen-day-old rats (6 gr...

We previously demonstrated that testicular spermatozoa can be preserved as frozen testicular sections, allowing us to preserve male gametes in less space than conventional methods. However, it remains unclear whether the testicular spermatozoa can be preserved for a long period using this procedure. In this study, we examined the function of testicular spermatozoa preserved as frozen testicular...

Prompt diagnosis and early treatment for testicular cancer is vital. To help with this a one-stop, urologist run, testicular clinic with testicular ultrasound scanning as an integral part of the clinic format was introduced to investigate patients in an efficient and timely manner. The aim of this study was to assess the feasibility and efficiency of running a one-stop testicular clinic. A pros...

Testicular germ cell tumors are the most common malignancy among young men. These are highly chemo-sensitive tumors with high cure rates. More than 95% of patients with testicular cancer present with a painless testicular mass. Here we describe a rare initial presentation of testicular cancer in a previously asymptomatic 22-year-old male who presented with widespread metastatic cannonball lesio...

Hypertension is one of the most common chronic diseases affecting millions people worldwide. The structure-based drug design targeting domains ACE important in treatment hypertension. domain specificity inhibition somatic and testicular by tripeptide GVR binding to specified active site has not been previously described. From this study, it was shown that significantly bound C-domain as compare...

later, she found him lying by the bed unable to communicate and unable to move his right limbs. On admission 3 h later, he was somnolent, globally aphasic, and he had central paresis of the facial nerve and spastic hemiplegia with brisk reflexes and extensor plantar response on the right side. There were no clinical signs of deep venous thrombosis. A few months earlier, he had been diagnosed as...

background: testicular torsion is a medical emergency that requires surgical intervention to reperfuse the affected testis. ischemia reperfusion injury is usually associated with proinflammatory cytokine generation and apoptosis of germ cells in the testes.objective: in this study we investigate the effect of ghrelin on the proinflammatory cytokines levels and germ cell apoptosis in testicular ...

Testicular torsion is predominantly a disease of adolescence, but age itself should not be an exclusion criterion for the diagnosis. A lack of suspicion for testicular torsion in older patients may result in a missed or delayed diagnosis which jeopardizes the chance of testicular salvage. In this article, we report a case of testicular torsion in a 55-year-old Chinese man.