The net accumulation of tetracyclines by Escherichia coli as a function of concentration was shown to be biphasic. At concentrations less than the bacteriostatic levels, the mode of uptake was not azide-sensitive and was considered to be physical adsorption on the cell surface. At concentrations above the minimal inhibitory level, a second, azide-sensitive, uptake component was functional in ad...

THE use of penicillin and sulphonamide, intravenous fluid replacement and gastric suction greatly reduced the mortality and complication rates of acute appendicitis. For the past few years streptomycin, aureomycin, and terramycin have been available, and the purpose of this investigation was to determine whether or not their use had resulted in any further improvement in the mortality and compl...

Tetracyclines, a broad-spectrum class of antibiotics, were discovered in the late 1940s, and became widely used because of their important advantages: they are inexpensive, safe, demonstrate good oral absorption, and are active against a broad range of bacterial pathogens. Unfortunately, as with most antibiotics, the emergence of microbial resistance to tetracyclines has become a serious proble...

OBJECTIVE To compare the effectiveness of tetracycline antibiotics versus control (placebo or conventional treatment) in rheumatoid arthritis (RA) for the reduction of disease activity as defined by American College of Rheumatology criteria. METHODS We searched Medline (1966-February 2002), Embase (1980-February 2002), and the Cochrane Controlled Trials Register (Issue 1, 2002 Cochrane Librar...

Staining of developing teeth due to tetracycline therapy has been publicized widely. However, the ability of tetracyclines to cause hypoplasia of enamel has not been accepted universally. This is a case report of enamel hypoplasia and staining presumably caused byahigh dosage of'tetracy'dines in childhood. Restoration of the teeth with bonded composite resins produced an esthetic result. Schwac...