Senescence of endothelial cells (ECs) may contribute to age-associated cardiovascular diseases, including atherosclerosis and hypertension. The functional and gene expression changes associated with cellular senescence are poorly understood. Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth fact...

intensify the pulmonary toxicity of MTX is unclear. RA itself can also affect the lung [6] usually leading to an interstitial pneumonia, either lymphocytic or chronic non-specific with various degrees of organizing pneumonia. None of these features was seen in the presented case. UIP and non-specific interstitial pneumonia (NSIP) could be ruled out as well. Also, the process did not fulfil the ...

Several epidemiological studies have supported the concept that high energy intake, obesity, and/or hyperinsulinemia are risk factors for colon cancer. Previously, it was shown that Zucker obese rats are more sensitive to chemically induced colon cancer than their lean counterparts. The present study investigated whether moderate (20–25%) dietary energy restriction (ER) would attenuate colon ca...

TGFhas been shown to be critical in the generation of CD4 CD25 Foxp3 regulatory T cells (Tregs). Because Th3 cells produce large amounts of TGF, we asked whether induction of Th3 cells in the periphery was a mechanism by which CD4 CD25 Tregs were induced in the peripheral immune compartment. To address this issue, we generated a TGF1-transgenic (Tg) mouse in which TGFis linked to the IL-2 promo...

Zhang J, Wu J, Gu C, Noble NA, Border WA, Huang Y. Receptor-mediated nonproteolytic activation of prorenin and induction of TGF1 and PAI-1 expression in renal mesangial cells. Am J Physiol Renal Physiol 303: F11–F20, 2012. First published April 25, 2012; doi:10.1152/ajprenal.00050.2012.—While elevated plasma prorenin levels are commonly found in diabetic patients and correlate with diabetic nep...

Human pancreatic ductal adenocarcinomas overexpress transforming growth factors (TGFs). This overexpression has been correlated with decreased patient survival. TGFs bind to a type II TGFreceptor (T RII) dimer, which heterotetramerizes with a type I TGFreceptor (T RI) dimer, thereby activating downstream signaling. Purpose and Experimental Design: To determine whether blocking TGFactions would ...

The objective of this study was to test the hypothesis that 13-cis-retinoic acid (CRA) and a-interferon (IFN-a) have antitumor activity in patients with early recurrence of prostate cancer measured by rising prostate-specific antigen (PSA) after local therapy, and that this activity is associated with the increase of plasma transforming growth factor 1 (TGF1). Thirty patients with a PSA > 7 ng/...

Panchapakesan, U., S. Sumual, C. A. Pollock, and X. Chen. PPAR agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. Am J Physiol Renal Physiol 289: F1153–F1158, 2005. First published May 10, 2005; doi:10.1152/ajprenal.00097.2005.—Peroxisome proliferator-activated receptor(PPAR ) are ligand-activated transcription factors that regulate cell growth, inflammation, li...

Introduction To date, pancreatic cancer remains one of the most lethal and least understood tumors known and is characterized as being resistant to most conventional chemotherapeutic regimens available (1). The fact that the etiology of this malignant gastrointestinal tumor is unknown, along with its invasive and metastatic properties, places a high priority on elucidating the molecular mechani...

A tissue culture system for rat prostatic epithelial cells was developed, and the effect of epidermal growth factor (EGF), transforming growth factor alpha (TGF-a), and transforming growth factor beta 1 (TGF-1) on these cells was evaluated. The primary culture was prepared by DNAse/collagenase dissociation of minced ventral prostates. Cells were initially plated in RPM I-i 640 medium containing...