Optical biosensors are low-cost, sensitive and portable devices that poised to revolutionize the medical industry. Healthcare monitoring has already been transformed by such devices, with notable recent applications including heart rate in smartwatches COVID-19 lateral flow diagnostic test kits. The commercial success impact of existing optical sensors galvanized research expanding its applicat...

Therapeutic drug monitoring (TDM) of biologics - encompassing the measurement (trough) concentrations and anti-drug antibodies is emerging as a valuable tool for clinical decision-making. While this strategy needs further validation, attention its implementation into clinic warranted. Rapid testing easy sampling are key to implementation. Here, we aimed evaluate feasibility volunteers’ percepti...

BACKGROUND AND OBJECTIVE The necessity of therapeutic drug monitoring (TDM) for vancomycin is controversial. The objective of the current review was to evaluate the available evidence for the necessity of TDM in patients given vancomycin to treat Gram-positive infections. METHODS Medline, Embase, Web of Sciences, the Cochrane Library and two Chinese literature databases (CNKI, CBM) were searc...

The benefits of a pharmacy-based, active therapeutic drug monitoring (TDM) service (ATM) on outcomes were examined in a prospective study at four hospitals. ATM involved pharmacokinetic dosage optimization at the start of treatment, subsequent Bayesian adaptive control, and frequent patient evaluation. Cost-effectiveness was calculated based on real costs. The ATM group comprised 105 patients a...

Introduction This study aimed to investigate the effect of smoking cessation on plasma clozapine (CLO) concentrations in long-term hospitalized Chinese male patients with schizophrenia treated CLO during COVID-19 pandemic. Methods Therapeutic drug monitoring (TDM) data for were collected at Beijing HuiLongGuan Hospital between December 1, 2019 (before cessation) and January 31, 2020 (after this...

BACKGROUND Therapeutic drug monitoring (TDM) is essential practice when dosing drugs with a narrow therapeutic index in order to achieve a plasma drug concentration within a narrow target range above the efficacy concentration but below the toxicity concentration. However, TDM with dose individualisation is challenging during a double-blind clinical trial with laboratory staff and investigators...

The immunosuppressants cyclosporine, tacrolimus, sirolimus, everolimus, and probably also mycophenolic acid require therapeutic drug monitoring (TDM)-guided dosing to ensure that blood concentrations are kept within the target range in transplant patients. Reliable, accurate, and precise test methods are therefore essential to effectively monitor levels and to make proper dose adjustments. Data...

ObjectivesAbiraterone acetate is registered for the treatment of metastatic castration-sensitive and resistant prostate cancer (mCRPC). Treatment outcome associated with plasma trough concentrations (Cmin) abiraterone. Patients a Cmin below target 8.4 ng/mL may benefit from optimization by dose increase or concomitant intake food. This study aims to investigate cost-effectiveness monitoring abi...

Interest in therapeutic drug monitoring (TDM) as an adjunct in the management of HIV infection has increased in recent years. The protease inhibitors (PIs) have stimulated the most interest in TDM as they have considerable interand intra-individual variability in plasma levels and marked potential for drug interactions that may lead to reduced or elevated PI plasma concentrations. There may als...