Deciphering the molecular underpinnings of a disease is often only the first step toward developing an effective treatment. The path from target identification to a successful therapeutic can be filled with numerous hurdles that call for creative strategies. This Select highlights recent advances in using gene therapy and engineered cells to treat cancers and chronic heart disease. Their succes...

Recent developments in antiretroviral therapeutics are summarized. The seven groups of antiretroviral drugs are briefly described, focussing on mechanism of action and new compounds. Updated recommendations of the International AIDS Society are reviewed.