BRAF is an important component of MAPK cascade. Mutation BRAF, in particular V600E, leads to hyperactivation the pathway and uncontrolled cellular growth. Resistance selective inhibitors mutated a major obstacle against treatment many cancer types. In this work, series new (imidazo[2,1-b]thiazol-5-yl)pyrimidine derivatives possessing terminal sulfonamide moiety were synthesized. Pan-RAF inhibit...