The thiazolidinone ring is found in compounds that have widespan biology activity and there mechanism-based evidence bearing this moiety inhibit P. aeruginosa PhzS (PaPzhS), a key enzyme the biosynthesis of virulence factor named pyocyanin. Ten novel derivatives were synthesised screened against PaPhzS, using two orthogonal assays. biological results provided by these 28 other compounds, whose ...

Searching for new types of biological activities among preliminarily identified hit compounds is a key challenge in modern medicinal chemistry. In our study, previously studied 3-[5-(1H-indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic acid (Les-6614) was screened antimicrobial, antifungal, anti-allergic, and antitumor activities. Moreover, cytotoxicity, molecular docking, SwissAdm...

derivatives of thiazolidinone ring systems are known to act as anti-hiv infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...