The molecular basis of the positive association between apoE4 genotype and CVD remains unclear. There is direct in vitro evidence indicating that apoE4 is a poorer antioxidant relative to the apoE3 isoform, with some indirect in vivo evidence also available. Therefore it was hypothesised that apoE4 carriers may benefit from alpha-tocopherol (alpha-Toc) supplementation. Targeted replacement mice...

(UV) light-induced skin damage. On the other hand, overexposure to UV radiation can lead to a pathological increase in melanin production. Epidermal hyper-pigmentation results from the increased activity of melanogenic enzymes such as tyrosinase. Tyrosinase oxidizes the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and DOPA to DOPA quinone, which are the first two rate limiting ...

A significant challenge in systems engineering and acquisition is to justify investments in system flexibility as opposed to buying more features or copies of a less-flexible systems. The Total Ownership Cost (TOC) has the advantages of having clear cause-effect relationships that are easy to understand and reason about. We present two TOC models for valuing flexibility that have been calibrate...

the quality of wastewater generated in any process industry is generally indicated by performance indices namely bod, cod and toc, expressed in mg/l. the use of toc as an analytica parameter has become more common in recent years especially for the treatment of industrial wastewater. in this study, several empirical relationships were established between bod and cod with toc using regression an...

In this issue of The Journal of Nuclear Medicine, Gabriel et al. (1) report their experience with 68Ga-labeled 1,4,7,10tetraazacyclododecane-N,N9,N99,N999tetraacetic acid-D-Phe1-Tyr3-octreotide (68Ga-DOTA-TOC) PET in a series of 84 patients with neuroendocrine tumors (NET). PET was more accurate with a higher detection rate than somatostatin receptor scintigraphy (using 111In-DOTA-TOC or 99mTc-...

A table-of-contents (TOC) provides a quick reference to a document’s content and structure. We present the first study on identifying the hierarchical structure for automatically generating a TOC using only textual features instead of structural hints e.g. from HTML-tags. We create two new datasets to evaluate our approaches for hierarchy identification. We find that our algorithm performs on a...

BACKGROUND There is a paucity of data on how to deliver complex interventions that seek to reduce the treatment gap for mental disorders, particularly in sub-Saharan Africa. The need for well-documented protocols which clearly describe the development and the scale-up of programs and interventions is necessary if such interventions are to be replicated elsewhere. This article describes the use ...