BACKGROUND To investigate the number of patients with congenital thrombophilia who presented an intracardiac thrombosis. METHODS Personal files were reevaluated together with a time-unlimited search of the literature. RESULTS Twenty-five patients with intracardiac thrombosis and congenital thrombophilia have been gathered from the literature including the two personal cases. The distributio...

OBJECTIVE To critically review the literature regarding inherited thrombophilia and recurrent fetal loss. DESIGN English-language literature review. PATIENT(S) Women who experienced repeated pregnancy wastage. INTERVENTION(S) Aspirin, glucocorticoids, heparin, and IV immunoglobulin for the prevention of miscarriage. MAIN OUTCOME MEASURE(S) Live birth, miscarriage, preeclampsia, and preg...

BACKGROUND There is limited evidence, so far, as to the optimal management of women with a prior obstetric history of antepartum complications attributed to thrombosis. We aimed to investigate the contribution of close antepartum surveillance on pregnancy outcome among women with prior antepartum complications attributed to thrombosis. METHODS The study was conducted on all women who were del...

Inherited thrombophilia is a genetically determined tendency to thrombosis. In 1965 the first family with antithrombin deficiency was described, and for many years this was the only identifiable cause of thrombophilia. More recently, pedigree and case–control studies have confirmed that the risk of venous thrombosis is increased by deficiencies of antithrombin, protein C, and protein S, and by ...

From the 'Charing Cross and Westminster Medical School, London, UK; 1RCCS Maggiore Hospital, Milan, Italy; Beth Israel Hospital, Boston USA; Universitv Hospital Leiden, The Netherlands; Research Centre of Medical Genetics, Moscow, The Russian Federation; WHO, Switzerland; Christian Medical College Hospital, Vellore, India; University of Lund, Malmö, Sweden; 'Institute of Clinical Genetics, Mosc...