...................................................................................................................................... i Acknowledgem ents .................................................................................................................... ii Table of

1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 2Graduate School of Science and Engineering, Yamaguchi University, Yamaguchi 753-8511, Japan 3Department of Veterinary & Biomedical Sciences, College of Agriculture & Biological Sciences, South Dakota State University, Brookings, SD 57006, USA 4Center of Infectious Disease and Signaling Research, Nation...

We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated micro-cavitation bubbles (μCBs) without requiring flow chambers or microfluidics. These μCBs expose adherent cells to a microTsunami, a transient microscale burst o...

Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has be...

Transition metal carbides (TMCs) are proposed as catalysts and supports for small particles to replace expensive late transition metals heterogeneous catalysts. High-throughput screening based on density functional theory...

This report is concerned with the analysis of data from “high-throughput” screening of possible drug compounds. High-throughput screening is a relatively new process yielding thousands of data points at a time, more than can be handled by traditional methods of biological data analysis. We examine a few methods for extracting knowledge from this data and also illustrate the use of descriptors f...

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In previous work we have shown how a max-plus algebraic model can be derived for cyclically operated high-throughput screening systems and how such a model can be used to design a controller to handle unexpected deviations from the predetermined cyclic operation during runtime. In this paper, we introduce an extension of this approach for high-throughput screening systems containing multi-capac...

This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along with methods for generating a fractionated sub-library. The best methods to store, maintain and prepare the library for screening are addressed...

High throughput screening has signiŽ cantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput proŽ ling addresses the issues of compound selectivity and speciŽ city. It combines conventional screening with data mining technologies to g...