Background: Surgeons agree on the benefits of operative treatment of tibial fractures – the most common of long bone fractures – with an intramedullary rod or nail. Rates of re-operation remain high – between 23% and 60% in prior trials – and the two alternative nailing approaches, reamed or non-reamed, each have a compelling biological rationale and strong proponents, resulting in ongoing cont...

secondary infection.5 Neurologic problems such as paralysis slow ambulation, an aid to healing. Psychiatric diseases may result in decreased patient compliance.6 Social factors also affect outcome. Use of tobacco slows fracture healing.7,8 Addictions to alcohol and street drugs impair patient compliance and increase the risk of complications. Poor family support also may limit patient complianc...

Background: Femoral shaft fractures are an incapacitating pediatric injury accounting for 1.6% of all pediatric bonyinjuries. Management of these fractures is largely directed by age, fracture pattern, associated injuries, built of the childand socioeconomic status of the family. We retrospectively evaluated the use of elastic stable intramedullary nail (ESIN)in surgical management of femoral s...

The key characteristic of a clinical researcher is probably the determination to deliver high quality studies despite all the inevitable bumps along the road. As well as the difficulties around funding and maintaining large collaborations that can deliver high impact multicentre studies, there are also more worrying challenges that threaten the robustness of the science. Some are widely recogni...

Open tibial shaft fractures are the most common open fractures, and many complications can occur. During the treatment period, infection leading to osteomyelitis was the most common complication. However, no consensus exists regarding the ideal management for such cases in the literature.The purposes of this retrospective study were to review the treatment of patients with chronic tibial shaft ...

PURPOSE OF THE STUDY Purpose of this anatomic study was to develop a new and safe technique of minimal invasive dorsal plate osteosynthesis for tibia shaft fractures. MATERIAL AND METHODS Sixteen paired adult lower limbs of eight different cadaveric specimens were examined. Anatomical prebending for each plate was done. Plates were inserted percutaneously, following plate fixation the neurova...

Recombinant human bone morphogenetic proteins (rhBMPs) have past a long journey in human orthopaedic surgery during the last 15 years. From the first reports of the use of rhBMPs in hostile environments such as critically-sized bone defects, avascular femoral head necrosis, unstable thoracolumbar vertebral fractures, instability between the atlas and axis due to rheumatoid arthritis; over the u...

3 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA The clinical role of prostaglandins in fracture healing has yet to be fully elucidated. Data from animal models have shown that some nonsteroidal anti-inflammatory medications (NSAIDs) inhibit fracture healing. However, a clear clinical association between prostaglandin inhibition and delayed fracture healing has not been ...

patients and methods the study population consisted of all patients with type iiia gastilo open fractures of tibial shaft, with or without fibula fracture (caused by trauma). after wound irrigation, debridement, and wound swab sampling for microbial culture, all patients received prophylactic antibiotic regimens in fitting with their wound class. no topical antibiotics were used with a 6-month ...

BACKGROUND Intramedullary nailing is commonly used for treating fractures of the tibial shaft. These fractures are one of the most common long bone fractures in adults. OBJECTIVES To assess the effects (benefits and harms) of different methods and types of intramedullary nailing for treating tibial shaft fractures in adults. SEARCH METHODS We searched the Cochrane Bone, Joint and Muscle Tra...