Premonitory urges are a cardinal feature in Tourette syndrome and are commonly viewed as the driving force of tics, building up before and subsiding after the execution of tics. Although the urge-tic interplay is one of the most preeminent features in Tourette syndrome, the temporal relationship between tics and urges has never been examined experimentally, mainly due to the lack of an appropri...

for some N. The only difficulty in the proof of these statements, beyond the methods already used in §§1-4, is the possibility that surfaces in $3 may have boundary values which are constant on some arcs of the circumference. Statement (1) yields a modified Morse theory; the usual requirement is that every k-cap contain a minimal surface g for which D [g] = a. But by assigning type numbers to b...

OBJECTIVES To determine whether juvenile obsessive-compulsive disorder (OCD) is familial and whether the rate of Tourette syndrome (TS) and tic disorders is higher among relatives of patients with OCD than among relatives of controls subjects. METHOD We assessed first-degree relatives of 35 juvenile OCD probands (aged 16 years or less) and 34 matched, psychiatrically unaffected control subjec...

Introduction: Stereotactically-guided core needle biopsies (CNB) of breast tumours allow histological examination of the tumour without surgery. Touch imprint cytology (TIC) of CNB promises to be useful in providing same-day diagnosis for counselling purposes and for planning future surgery. Having addressed the issue of accuracy of immediate microscopic evaluation of TIC, we wanted to re-exami...

Silicon has a high specific capacity of 4200 mAh/g as lithium-ion battery anodes, but its rapid capacity fading due to >300% volume expansion and pulverization presents a significant challenge for practical applications. Here we report a core-shell TiC/C/Si inactive/active nanocomposite for Si anodes demonstrating high specific capacity and excellent electrochemical cycling. The amorphous silic...

Web conferencing tools have entered the mainstream of business applications. Using web conferencing for IEEE conferences has a good potential of adding value to both organizers and participants. Authors propose a concept of Truly Integrated Conference (TIC) according to which a multi-point worldwide-distributed network of conference online authors/participants will enhance the standard (central...

Simulink has been used widely as an industry tool to model and simulate embedded systems. With increasing usage of embedded systems in real-time safety-critical situations, Simulink is deficient to cope with the requirements of high-level assurance and timing analysis. In this paper, we present a systematic approach to translate Simulink diagrams to Timed Interval Calculus (TIC), a notation ext...

Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcription factor. ZFHX4 is required to maintain TIC-associated and normal human neural precursor cell phe...

Tourette Syndrome (TS) is a chronic neurologic disorder characterized by the childhood onset of multiple motor and phonic tics that wax and wanes over time [1]. The syndrome is common (1%) and the aetiology is complex (mostly genetic) and 90% of people have co-morbid psychiatric disorders and reduced quality of life [2]. In facts Tourette syndrome is the most common cause of tics. Other tic dis...

Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as...