Sensitivity analysis ● In the deterministic sensitivity analysis the ICER ranged between 20,636 and 47,428 €/QALY. The parameters with the greatest impact were the modification of the utility values, the difference in efficacy between treatments and the time horizon (Figure 2). ● In the probabilistic sensitivity analysis the probability of UMEC/VI being cost-effective was 80.3% at a willingness...

We consider space-times which in addition to admitting an isolated horizon also admit Killing horizons with or without an event horizon. We show that an isolated horizon is a Killing horizon provided either (1) it admits a stationary neighbourhood or (2) it admits a neighbourhood with two independent, commuting Killing vectors. A Killing horizon is always an isolated horizon. For the case when ...

We measure the expansion rate of recent Universe and calibration scale baryon acoustic oscillation (BAO) from low-redshift data. BAO relies on scale, i.e., sound horizon at end drag epoch $r_d$, which often imposes a prior cosmic microwave background (CMB) measurement Planck satellite. In order to make really independent measurements $H_0$, we leave $r_d$ completely free use data sets combined ...