A number of bone tissue engineering strategies use porous three-dimensional scaffolds in combination with bioreactor regimes. The ability to understand cell behaviour relative to strain profile will allow for the effects of mechanical conditioning in bone tissue engineering to be realized and optimized. We have designed a model system to investigate the effects of strain profile on bone cell be...

This paper introduces backward conditioning. Like forward conditioning (used in conditioned slicing), backward conditioning consists of specialising a program with respect to a condition inserted into the program. However, whereas forward conditioning deletes statements which are not executed when the initial state satisfies the condition, backward conditioning deletes statements which cannot c...

Strategies to design novel vascular scaffolds are a continuing aim in tissue engineering and often such designs encompass the use of recombinant factors to enhance the performance of the scaffold. The established use of cell secretion utilized in feeder systems and conditioned media offer a source of paracrine factors, which has potential to be used in tissue-engineered (TE) scaffolds. Here we ...

Introduction Tissue conditioners are used for conditioning of denture-bearing inflamed mucosa by ill-fitting dentures prior to fabricating new dentures, for relining the existing dentures, and for provisional relining of immediate dentures and ill-fitting dentures [1-2]. Tissue conditioners have also been used as functional impression materials [1-3]. Their efficacy as functional impression mat...

The activity of dopamine (DA)-containing neurons in the ventral tegmental area (VTA) is a key mechanism in mesolimbic reward processing that has modulatory effects on different diencephalic structures like hippocampus (HIP), and receives inhibitory feedback and excitatory feed forward control. In addition, within the hippocampus, DA receptors are mostly located in the dorsal part (CA1) and dopa...

Denture-induced hyperplasia is a reactionary lesion to ill-fittingdentures. It mostly asymptomatic, but the patient may present pain in case of ulceration. Its etiology multifactorial. main cause chronic trauma; usually due prosthetic instability.Its diagnosis based on clinical examination completed by anatomopathological for very extensive lesions. The management denture-induced depends aspect...

We introduce a new reinforcement-learning model for the role of the hippocampus in classical conditioning, focusing on the differences between trace and delay conditioning. In the model, all stimuli are represented both as unindividuated wholes and as a series of temporal elements with varying delays. These two stimulus representations interact, producing different patterns of learning in trace...

Classical conditioning paradigms, such as trace conditioning, in which a silent period elapses between the offset of the conditioned stimulus (CS) and the delivery of the unconditioned stimulus (US), and delay conditioning, in which the CS and US coterminate, are widely used to study the neural substrates of associative learning. However, there are significant gaps in our knowledge of the neura...