DNA protein cross-links (DPC), DNA interstrand cross-links (ISCL), and DNA single strand breaks following treatment of experimental ovarian tumor cells (O-342) with five new metal complexes (three platinum, one titanium, one ruthenium compounds) were investigated at 6, 24, and 48 h after drug exposure and compared with their in vitro growth inhibitory potential. cis-Diamminedichloroplatinum(II)...

objective(s):anodized treated titanium surfaces, have been proposed as potential surfaces with better cell attachment capacities. we have investigated the adhesion and proliferation properties of h9c2 cardiac myoblasts on anodized treated titanium surface.  materials and methods: surface topography and anodized tubules were examined by high-resolution scanning electron microscopy (sem). control...

Organic compounds in wastewaters coming from textile and pharmaceutical industry generated multiple harmful effects on the environment and the human health. One of them is the methyl orange (MeO), an azoic dye considered to be a recalcitrant compound. The heterogeneous photocatalysis emerges as an alternative for treating this type of hazardous compounds, through the generation of OH radicals u...

To develop new synthons for the syntheses of organofluorine compounds, the treatment of Halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane, (1) with 4-methylbenzenethiol (2) in the presence of sodium hydride gave 1-chloro-2,2,2-trifluoroethyl 4-methylphenyl sulfide (3), which was oxidized with m-chloroperbenzoic acid (m-CPBA) to the corresponding sulfoxide (4) and sulfone (5). Reaction of 3 and ...

Titanium(IV) compounds are excellent anticancer drug candidates, but they have yet to find success in clinical applications. A major limitation in developing further compounds has been a general lack of understanding of the mechanism governing their bioactivity. To determine factors necessary for bioactivity, we tested the cytotoxicity of different ligand compounds in conjunction with speciatio...

The molecular structures of the titanium(III) borohydride complexes Ti(BH4)3(PEt3)2 and Ti(BH4)3(PMe2Ph)2 have been determined. If the BH4 groups are considered to occupy one coordination site, both complexes adopt distorted trigonal bipyramidal structures with the phosphines in the axial sites; the P-Ti-P angles deviate significantly from linearity and are near 156 degrees. In both compounds, ...