Although post-ischemic stroke process is essential for the repair of infarcted area, excessive inflammation during this can induce tissue damage. Damage-associated molecular patterns (DAMPs) released from injured cells in early phase ischemic cytokine and chemokine production by activating microglia, thereby facilitating neutrophil lymphocyte infiltration. However, inhibition neutrophils, lymph...

BackgroundCoronary calcification impairs stent delivery and optimal expansion, a significant predictor of subsequent thrombosis restenosis. Current calcium ablative technologies may be limited by guidewire bias periprocedural complications. Intravascular lithotripsy (IVL) delivers acoustic pressure waves to modify calcium, enhance vessel compliance, optimize deployment. The Disrupt CAD III stud...

Abstract Objectives: The mechanosensitive Ca 2+ion channels, Piezo1, converts the mechanical stimulus into cell signals in a variety of immune cells. However, pathophysiological property Piezo1 oral polymicrobial infectious disease periodontitis is largely unknown. This study investigated role inflammatory and phagocytic reactions by RAW264.7 macrophages response to exposures periodontal pathog...

Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed to investigate whether TLR- 4 896A/G variation is related to migraine headaches in an Iranian po...

BACKGROUND One-third of the world's population is infected with Mycobacterium tuberculosis. Investigation of Toll-like receptors (TLRs) has revealed new information regarding the immunopathogenesis of this disease. Toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. Toll-like receptor 2 and TLR-4 have been identified in association with tuberculosis in...

PURPOSE To identify the distribution, differential Toll-like receptor (TLR) expression, and functional contribution of monocyte subpopulations in the inflammatory stage of Eales' disease (ED). METHODS Peripheral blood mononuclear cells were isolated from nine patients during the inflammatory stage of ED and nine age- and sex-matched healthy controls. The expression of CD14, CD16, TLR-2, and T...