Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc). This conversion has been used for in vitro assays including serial protein misfolding amplification and real-time quaking induced conversion (RT-QuIC). RT-QuIC can be used for the ...

AIM To evaluate the safety and feasibility of a new technology combining low-pressure pneumoperitoneum (LPP) and abdominal wall lift (AWL) in laparoscopic total mesorectal excision (TME) for rectal cancer. METHODS From November 2015 to July 2017, 26 patients underwent laparoscopic TME for rectal cancer using LPP (6-8 mmHg) with subcutaneous AWL in Qilu Hospital of Shandong University, Jinan, ...

This study aims to validate the oncologic outcomes of anastomotic leakage (AL) after laparoscopic total mesorectal excision (TME) in a large multicenter cohort. The impact of AL after laparoscopic TME for rectal cancer surgery has not yet been clearly described. This was a multicenter retrospective study of 1083 patients who underwent laparoscopic TME for nonmetastatic rectal cancer (stage 0-II...

Abstract The complexity of the tumor microenvironment (TME) severely hinders therapeutic effects various cancer treatment modalities. TME differs from normal tissues owing to presence hypoxia, low pH, and immune-suppressive characteristics. Modulation reverse growth equilibrium is considered an effective way treat tumors. Recently, polymeric nanomedicines have been widely used in therapy, becau...

The spread of the abnormal conformation of the prion protein, PrP(Sc), within the spinal cord is central to the pathogenesis of transmissible prion diseases, but the mechanism of transport has not been determined. For this report, the route of transport of the HY strain of transmissible mink encephalopathy (TME), a prion disease of mink, in the central nervous system following unilateral inocul...

Background: Anastomotic leakage is a major complication after rectal cancer surgery. We investigated risk factors that were associated with symptomatic anastomotic leakage after total mesorectal excision. Method: Between 1996 and 1999 patients with operable rectal cancer were randomised between short-term radiotherapy followed by TME and TME alone. Eligible Dutch patients who underwent an anter...

Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with limited therapy options and dismal prognosis. In recent years, the role of immune cells within the tumor microenvironment (TME) has become a major area of interest. In this review, we discuss the current knowledge of heterogeneity in immune cell content and checkpoint expression in MPM in relation to prognosis and predictio...

Objective: This study aimed to discuss the feasibility, safety, eradication effect, short-term outcomes, and midto long-term survival rates of laparoscopic total mesorectal excision (TME) in treating middle/low T3 rectal cancer. Methods: Patients with middle/low T3 rectal cancer that received an operation in our hospital from January 2009 to December 2012 were nonrandomly divided into laparosco...

The available energy of several poultry by-product meal products were determined by various experimental methods. It is imperative to determine the accurate available energy value for these products for proper diet formulation and product usage. Leghorn roosters and turkeys were tube fed the products for the assay based on the True Metabolizable Energy (TME) system. Three week old battery reare...

Tumors are surrounded and infiltrated by a variety of stromal cell types, including fibroblasts, immune cells, and vascular endothelial cells, which interact with malignant cells to generate the tumormicroenvironment (TME). This complex environment is thought to be regulated by the tumor in order to promote its survival and progression and thus constitutes a potential target for cancer therapy....