Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially...

For more than 20 years, tamoxifen has been the gold standard for the adjuvant treatment of postmenopausal women with hormone-responsive early breast cancer. However, recent randomized trials have shown efficacy and tolerability benefits with the third-generation aromatase inhibitor anastrozole, resulting in an increased use of this agent in the adjuvant setting. Data on anastrozole's long-term ...

In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age±SD, 8.5±3.9years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high g...

Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially...

Abstract: Aim: To find out the safety and tolerability of cisplatin either given as individual therapy or in combination with other anticancer drugs radiotherapy. Materials Methods: A prospective observational study was conducted oncology department (inpatient) tertiary care hospital. The data collected from in-patient after considering inclusion exclusion criteria for a period 6 months. Safety...

The National guidelines "2022 Prevention of chronic non-communicable diseases in the Russian Federation" subsection "Pharmacotherapy tobacco dependence" contain insufficiently correct statements about contraindications for use, efficacy and tolerability cytisine. This paper presents a detailed analysis these statements.

Analyses of data on safety/tolerability from clinical drug trials seek primarily to provide a reliable description of potential tolerability or toxicity problems that may occur in clinical practice. In addition, formal tests of the hypothesis that the experimental and control drugs present equal risk of adverse event (AE) occurrence often are carried out for each AE that occurs with some minimu...