Computational full-atom models of the agonist lipopolysaccharide (LPS)-bound Toll-like receptor 4 (TLR4) embedded into a realistic plasma membrane reveal dynamic functional and structural insights TLR4 activation signaling across membrane, ectodomain bouncing movement, dimerization patterns (symmetric asymmetric) intracellular Toll/interleukin-1 (TIR) domain. These studies unveil molecular aspe...

background: the pathogenesis of inflammatory bowel disease is complex and multifactorial. studies have led to the current concept that toll-like receptors represent key mediators of innate host defense in the intestine, and they are involved in maintaining mucosal as well as commensal homeostasis. we studied the possibility of simvastatin and antagonist of receptors of interleukin-1 for pharmac...

The pathogenicity of Candida glabrata to patients remains poorly understood for lack of convenient animal models to screen large numbers of mutants for altered virulence. In this study, we explore the minihost model Drosophila melanogaster from the dual perspective of host and pathogen. As in vertebrates, wild-type flies contain C. glabrata systemic infections yet are unable to kill the injecte...

In this paper we address the problem of dynamic pricing for toll lanes on freeways. The proposed toll mechanism is broken up into two parts: (1) the supply side feedback control that computes the desired split ratios for the incoming traffic flows between the general purpose and the toll lanes; and (2) the demand side price setting algorithm that aims to enforce the computed split ratios. The s...

In this work, we calculate the limit distribution of the total cost incurred by splitting a tree selected at random from the set of all finite free trees. This total cost is considered to be an additive functional induced by a toll equal to the square of the size of tree. The main tools used are the recent results connecting the asymptotics of generating functions with the asymptotics of...