Purpose: This study was designed to develop and evaluate chitosan films containing ciprofloxacin and diclofenac sodium for the topical treatment of periodontitis. Methods: Chitosan films containing ciprofloxacin alone and in combination with diclofenac sodium were prepared by solvent casting method. Some of the drug-loaded films were crosslinked with 2% gluteraldehyde for 2 and 4 h, respectivel...

Department of Pharmaceutical Chemistry, Devsthali Vidyapeeth College of Pharmacy, Rudharpur, Uttrakhand – 263153, India Abstract Nimesulide is a second generation non–steroidal anti–inflammatory agent, which is widely used in the long term therapy of rheumatoid arthritis, in alleviating pain and inflammation. But its short half-life (only 3–4 hr), so its causes more fluctuation. After oral admi...

CLINICAL QUESTION What is the best treatment for traumatic corneal abrasion? RESULTS Eye patching does not reduce pain in patients with corneal abrasions. Topical diclofenac does reduce pain in patients with corneal abrasions IMPLEMENTATION Pitfalls to avoid when treating abrasions: Treatment of small abrasions Treatment of larger abrasions When to refer for specialist treatment.

The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property o...

To compare the difference in pain score during flexible TRIAL DESIGN: cystoscopy between patients undergoing the procedure with plain lubricating gel only and plain gel with diclofenac suppository in a randomized control trial. : A total of 60 male patients with an indication of flexible cystoscopy METHODS were enrolled in a prospective, randomized controlled study. Patients were randomized i...

background: the need to relieve pain and inflammation after periodontal surgery and the side effects of systemic drugs and advantages of topical drugs, made us to evaluate the effect of diclofenac mouthwash on periodontal postoperative pain.     methods: in this double-blind, randomized clinical trial study 20 quadrants of 10 patients(n=20) aged between 22-54 who also acted as their own control...

In vivo enamel fluoride (F) uptake as a function of time after a single application of a new topical APF gel, MinuteGelTM (gel A) , was compared to a control APF gel, Nupro ® (gel B). The retained F in enamel after different post-treatment intervals also was assessed. Forty orthodontic patients aged 10-16 with four premolars scheduled for extraction were divided into two subgroups according to ...

background the goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability. material and methods to select the best formulation, formulations with different concentration of carbomer and hpmc were evaluated for their appearance. then evaluated for physicochemical characteristics such as rheologic behavior...

Biofreeze, a topical analgesic, is commonly used as a coupling medium during therapeutic ultrasound to add greater relief of pain, although it may block transmission of ultrasound energy. Our objective was to compare a mixture of 1-part Biofreeze and 3-parts ultrasound gel to 100% ultrasound gel to assess intramuscular heating and perceived sensation of heat. Fifteen participants received a con...