Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...

conclusions combination therapy with tretinoin plus topical corticosteroids is safe and effective and provides an alternative in the treatment of patients with vitiligo. objectives recent studies suggest that administration of topical tretinoin, with a corticosteroid, diminishes skin atrophy without impacting the steroid’s anti-inflammatory effects. patients and methods a placebo-controlled, pa...

the purpose of the research was to formulate microspheres of acyclovir (acv) using mucoadhesive polymers, sodium alginate and chitosan. calcium chloride was used as the ionotropic gelling agent. sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...

bioassays were conducted to assess the contact toxicity of two plant essential oils against adults of sitophilus granarius (l.) and tribolium confusum jacquelin du val. essential oils were extracted from seeds of carum copticum l. and cuminum cyminum l. contact toxicity was assessed by topical application and adult mortality was counted 1, 2, 6 and 24 h after exposure. bioassays were carried ou...

the topical delivery of non-steroidal anti-inflammatory drugs (nsaids) such as ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. however, it is dif...

the objective of this study was to determine the effectiveness of topical administration of honey in prevention of or reduction in post-surgical peritoneal adhesions in dog. the study was conducted on 18 adultfemale mixed-breed dogs with a mean ± sd weight of 20 ± 4.25 kg. a standardized surgical trauma (serosaltrauma model) was made in the dogs’ descending colon to induce adhesion formation. t...

purpose: to present two patients with acute corneal hydrops, superimposed with infectious keratitis using topical steroids. patients and findings: the first case was a 44-year-old man with acute corneal hydrops in his left eye which was on topical steroids for one week. visual acuity was hand motion at presentation and there was a large epithelial defect with stromal infiltration and corneal ed...