BACKGROUND This is the 31st Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of January 1, 2013, 57 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 8.08 [7.10, 11.63] (median [25%, 75%]) minutes, creating a near real-time national exposure and information database and survei...

It isn’t well understood how chronic low-level exposures to toxic metals contribute to disease, but a growing number of studies suggest epigenetic mechanisms may play a role. In this issue of EHP, investigators report a novel association between metals exposure and DNA hydroxymethylation, an epigenetic modification that has only recently entered the research spotlight. Epigenetic modifications ...

INTRODUCTION This is the 33rd Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of 1 January 2015, 55 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 9.52 [7.40, 13.6] (median [25%, 75%]) minutes, creating a near real-time national exposure and information database and survei...

BACKGROUND This is the 30(th) Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of July 1, 2012, 57 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 7.58 [6.30, 11.22] (median [25%, 75%]) min, creating a near real-time national exposure and information database and surveillanc...

itself. In turn, ingested inorganic arsenic—the more toxic form of the metal—has been shown to change the composition of the gut community. Researchers exploring this newer angle report in EHP that arsenic exposure appears to alter not only the composition of the gut microbiome but also the metabolites it produces. Study leader Kun Lu of the University of Georgia, Athens, and colleagues exposed...

Historically the Brazilian pharmaceutical industry went through different phases, which reflected, at least in part, national economic stages. Until the last decade Brazil was dominated by foreign pharmaceutical industry. This has been changing as some national companies, supported by the federal government, have started developing new molecules derived from academic research, as well as produc...

BACKGROUND This is the 28th Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). All US poison centers upload case data automatically with a median time interval of 19.0 [11.9, 40.6] (median [25%, 75%]) minutes, creating a near real-time national exposure and information database and surveillance system. METHODOLOGY We analyzed the c...

Metabolomics first burst into the toxicology arena approximately 10–12 years ago, experiencing rapid growth as a science in the intervening period (Fig. 1). Though metabolomics still trails the publication rates of its sister technologies, genomics and proteomics, it is closing the gap in terms of both the numbers of publications and the quality of those publications. One continuing source of c...

Steve Kleeberger and Matt Longnecker step up to serve with me as interim deputy editors in the absence of a full-time permanent editor. Steve and Matt have given generously of their time, expertise, and energy in helping to maintain EHP ’s scientific quality during a time of transition. Given EHP ’s broad scope of coverage, however, we felt the need to likewise broaden the scope of our science ...

For Gilliland and colleagues’ work on uranium mining and lung cancer among Navajo men between 1969 and 1993 see J Occup Environ Med 2000; 42: 278–83 of the dangers. Some took ore and radioactive fossil wood home. Waste ore was used as building material for homes. Early cohorts of miners were “really heavily exposed”, says Jonathan Samet (Keck School of Medicine, Institute of Global Health, Univ...