نتایج جستجو برای: toxigenic clostridium difficile

تعداد نتایج: 27741  

2018
Marina Muñoz Dora I. Ríos-Chaparro Giovanny Herrera Sara C. Soto-De Leon Claudia Birchenall Darío Pinilla Juan M. Pardo-Oviedo Diego F. Josa Manuel A. Patarroyo Juan D. Ramírez

Clostridium difficile (CD) produces antibiotic associated diarrhea and leads to a broad range of diseases. The source of CD infection (CDI) acquisition and toxigenic profile are factors determining the impact of CD. This study aimed at detecting healthcare facility onset- (HCFO) and community-onset (CO) CDI and describing their toxigenic profiles in Bogotá, Colombia. A total of 217 fecal sample...

2017
Eman N Abu-Khader Eman F Badran Asem A Shehabi

Clostridium difficile is commonly found in the intestine of infants without causing any disease. This study investigated the most important epidemiological features of C. difficile strains colonizing intestine of Jordanian infants. A total of 287 fecal samples were collected from infants admitted to the Jordan University Hospital (JUH) over the period of 2015. Samples were cultured for C. diffi...

2015
Marc Monot Catherine Eckert Astrid Lemire Audrey Hamiot Thomas Dubois Carine Tessier Bruno Dumoulard Benjamin Hamel Amandine Petit Valérie Lalande Laurence Ma Christiane Bouchier Frédéric Barbut Bruno Dupuy

The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found in the same location and is replaced in non-toxigenic strains by a highly cons...

Journal: :Antimicrobial agents and chemotherapy 2014
Hans H Locher Peter Seiler Xinhua Chen Susanne Schroeder Philippe Pfaff Michel Enderlin Axel Klenk Elvire Fournier Christian Hubschwerlen Daniel Ritz Ciaran P Kelly Wolfgang Keck

Clostridium difficile is a leading cause of health care-associated diarrhea with significant morbidity and mortality, and new options for the treatment of C. difficile-associated diarrhea (CDAD) are needed. Cadazolid is a new oxazolidinone-type antibiotic that is currently in clinical development for treatment of CDAD. Here, we report the in vitro and in vivo antibacterial evaluation of cadazol...

2016
Tian-tian Tian Jian-hong Zhao Jing Yang Cui-xin Qiang Zhi-rong Li Jing Chen Kai-yue Xu Qing-qing Ciu Ru-xin Li

Clostridium difficile is a spore-forming, gram-positive, anaerobic bacillus that can cause C. difficile infection (CDI). However, only a few studies on the prevalence and antibiotic resistance of C. difficile in healthy individuals in China have been reported. We employed a spore enrichment culture to screen for C. difficile in the stool samples of 3699 healthy Chinese individuals who were divi...

2017
Laura Behar David Chadwick Angela Dunne Christopher I. Jones Claire Proctor Chakravarthi Rajkumar Paula Sharratt Philip Stanley Angela Whiley Mark Wilks Martin J. Llewelyn

OBJECTIVES To establish risk factors for Clostridium difficile colonization among hospitalized patients in England. METHODS Patients admitted to elderly medicine wards at three acute hospitals in England were recruited to a prospective observational study. Participants were asked to provide a stool sample as soon as possible after enrolment and then weekly during their hospital stay. Samples ...

2016
Xiaoxia Zhang Xiaohui Wang Jingyu Yang Xiaohua Liu Lin Cai Zhiyong Zong

BACKGROUND A prospective study was performed to investigate the prevalence of colonization among ICU patients and to examine whether asymptomatic carriers were the source of subsequent C. difficile infection (CDI) and acquisition of toxigenic C. difficile. METHODS Rectal swabs were collected from adult patients on admission to and at discharge from a 50-bed medical ICU of a major referral hos...

Journal: :Jundishapur Journal of Microbiology 2022

Background: Clostridium spp. spores are resistant to many factors, including alcohol-based disinfectants. The presence of clostridial in a hospital environment may lead infection outbreaks among patients and health care workers. Objective: This study is aimed detect the aurology using C diff Banana Broth™ assess antibiotic sensitivity toxinotypes isolates. Methods: After diagnosing COVID-19 med...

Journal: :The Journal of the American Board of Family Practice 2000
D J Kovacs T Berk

Antibiotic-associated diarrhea is common in both inpatient and outpatient settings, and 15% to 20% of the cases are caused by Clostridium difficile. 1 Although antibiotic therapy with metronidazole or other agents is effective for most patients with C difficile-associated diarrhea, approximately 10% to 20% of patients receiving treatment for C difficile infection will experience a relapse follo...

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