نتایج جستجو برای: tp53 codon 72 polymorphism

تعداد نتایج: 220998  

Journal: :European Journal of Cancer Supplements 2003

2010
Mehdi Nikbahkt Dastjerdi Mansour Salehi Mohammad Rabbani

Background: The polymorphic variants at codon 72 of the p53 gene, encoding either proline or arginine at residue 72, produce marked change in the structure of p53. From the evidence that the DNAmismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that the codon 72 variation may influence the prevalence of microsatellite instability; a feature of malignancies as...

Journal: :Carcinogenesis 2007
Kexin Chen Zhibin Hu Li-E Wang Erich M Sturgis Adel K El-Naggar Wei Zhang Qingyi Wei

Tumor protein 53 (TP53), a transcriptional factor, induces expression of the B-cell lymphoma 2-associated X protein (BAX) gene by directly binding to the TP53-binding element in the BAX promoter but inhibits B-cell lymphoma 2 (BCL2) promoter-driven transcription through a responsive region in the BCL2 promoter. Therefore, we hypothesized that single-nucleotide polymorphisms (SNPs) of BAX and BC...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Kiruthiga Perumal Vijayaraman Mohanasundari Veluchamy Pravina Murugesan Karutha Pandian Shanmugiah Pandima Devi Kasi

BACKGROUND We investigated the association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk in women especially in the Southern part of India. METHODS Genotyping was performed for 50 breast cancer women and 50 controls to determine the status of p53 exon 4 codon 72 polymorphism and exon 7 codon 249 mutation and their possible role in breast cancer risk. RESULTS ...

2013
Maryam Taghi Zoghi Anna Boyajyan

The p53 gene is one of the most extensively studied human genes because of its role as a tumor suppressor. A common polymorphism of the p53 gene at codon 72 has been associated with human cancer susceptibility and prognosis. Human papilloma virus (HPV) has also been suggested to be involved in the pathogenesis of esophageal cancers. In this study, we investigated codon 72 polymorphism in 40 eso...

Journal: :BMC Urology 2005
Gustavo J Leiros Silvia R Galliano Mario E Sember Tomas Kahn Elisabeth Schwarz Kumiko Eiguchi

BACKGROUND Infections with high-risk human papillomaviruses (HPVs), causatively linked to cervical cancer, might also play a role in the development of prostate cancer. Furthermore, the polymorphism at codon 72 (encoding either arginine or proline) of the p53 tumor-suppressor gene is discussed as a possible determinant for cancer risk. The HPV E6 oncoprotein induces degradation of the p53 prote...

Journal: :The Kaohsiung journal of medical sciences 2013
Fang-Ming Chen Fu Ou-Yang Sheau-Fang Yang Eing-Mei Tsai Ming-Feng Hou

There are clear discrepancies between ethnicity and geographic area regarding the peak age incidence and mortality of breast cancer. Underlying variances include genetic, environmental, and socioeconomic factors. The wild-type p53 codon has two common polymorphic variants from a single-base-pair substitution at codon 72, where either C-C-C encodes proline (p53-p72) or C-G-C encodes arginine (p5...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید