9-cis-Retinoic acid (9-cis-RA) and all-trans-RA (ATRA) are naturally occurring hormones. The nuclear receptors that mediate the effects of retinoids are the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). ATRA binds RAR with high affinity but does not bind to RXR, whereas 9-cis-RA, an isomer of ATRA, is a ligand that binds and transactivates both RARs and RXRs. The goals of ...

PURPOSE Heat shock protein 90 (Hsp90) is essential for the posttranslational control of many regulators of cell growth, differentiation, and apoptosis. 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG) binds to Hsp90 and alters levels of proteins regulated by Hsp90. We conducted a phase I trial of 17-AAG in pediatric patients with recurrent or refractory neuroblastoma, Ewing's sarcoma, osteosar...

PURPOSE To evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of mapatumumab, a fully human monoclonal antibody targeting tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), in combination with gemcitabine and cisplatin. EXPERIMENTAL DESIGN Patients with advanced solid tumors received gemcitabine 1,250 mg/m(2) i.v. on days 1 and 8 and cispla...

PURPOSE A dose-escalation, phase I study evaluated the safety, pharmacokinetics, and efficacy of a weekly 1-h regimen of kahalalide F, a cyclic depsipeptide isolated from the marine mollusk Elysia rufescens, in adult patients with advanced solid tumors and no standard treatment available. EXPERIMENTAL DESIGN Patients received an i.v. 1-h infusion of kahalalide F once weekly until disease prog...

INTRODUCTION The aim of this study was to ascertain the outcomes of chronic hepatitis B (CHB) infection following immunosuppressive therapy in 38 consecutive oriental patients with systemic rheumatic diseases. MATERIALS AND METHODS This is a retrospective consecutive, non-comparative study. RESULTS The majority of patients were female (26, 68.4%), predominantly Chinese (92.1%), with a mean ...

Abstract Background The use of pyronaridine-artesunate (PA) has been associated with scarce transaminitis in patients. This analysis aimed to evaluate the hepatic safety profile repeated treatment PA versus artemether–lumefantrine (AL) patients consecutive uncomplicated malaria episodes Bobo-Dioulasso, Burkina Faso. Methods study analysed data from a clinical trial conducted 2012 2015, which pa...

PURPOSE To determine the safety, maximum tolerated dose, and pharmacokinetic-pharmacodynamic profile of a histone deacetylase inhibitor, LAQ824, in patients with advanced malignancy. PATIENTS AND METHODS LAQ824 was administered i.v. as a 3-h infusion on days 1, 2, and 3 every 21 days. Western blot assays of peripheral blood mononuclear cell lysates and tumor biopsies pretherapy and posttherap...

BACKGROUND Concurrent infection with multiple pathogens is common in tropics, posing diagnostic and treatment challenges. Although co-infections of dengue, malaria, leptospirosis and typhoid in various combinations have been described, data on dengue and scrub typhus co-infection is distinctly limited. METHODOLOGY This study was a retrospective analysis of dengue and scrub typhus co-infection...

PURPOSE Ipilimumab is a first-in-class immune checkpoint inhibitor approved for treatment of metastatic melanoma but not studied in children until this phase I protocol. EXPERIMENTAL DESIGN This study examined safety, pharmacokinetics, and immunogenicity, and immune correlates of ipilimumab administered to subjects ≤21 years old with recurrent or progressive solid tumors. Dose escalation coho...

Department of Internal Medicine, McMaster University, Hamilton, Ontario Correspondence: Dr Karim Ladak, Department of Internal Medicine, McMaster University, 1280 Main Street West, HSC-3W10, Hamilton, Ontario L8S 4K1. Telephone 905-962-2786, fax 905-529-0066, e-mail [email protected] CASE PRESENTATION A 74-year-old woman presented to the emergency department after blood cultures drawn by...