Microarray analyses of gene knockouts have traditionally focused on the identification of genes whose mean expression is different in knockout and wild-type mice. However, recent work suggests that changes in the variability of gene expression can have important phenotypic consequences as well. Here, in an unbiased sample of publicly available microarray data on gene expression in various knock...

By covalently binding a photoswitchable linker across the binding groove of the PDZ2 domain, a small conformational change can be photo-initiated that mimics the allosteric transition of the protein. The response of its binding groove is investigated with the help of ultrafast pump-probe IR spectroscopy from picoseconds to tens of microseconds. The temperature dependence of that response is com...

The health of tens of millions of people world-wide is at risk from drinking arsenic-contaminated well water. In most cases this arsenic occurs naturally within the sub-surface aquifers, rather than being derived from identifiable point sources of pollution. The mobilization of arsenic into the aqueous phase is the first crucial step in a process that eventually leads to human arsenicosis. Incr...

To be sure, the other America is not impoverished in the same sense as those poor nations where millions cling to hunger as a defense against starvation. This country has escaped such extremes. That does not change the fact that tens of millions of Americans are, at this very moment, maimed in body and spirit, existing at levels beneath those necessary for human decency...They are without adequ...

Future surveys for transiting extrasolar planets, including the space-based mission Kepler (1), are expected to detect hundreds of Jovian mass planets and tens of terrestrial mass planets. For many of these newly discovered planets, the intervals between successive transits will be measured with an accuracy of 0.1–100 minutes. We show that these timing measurements will allow for the detection ...

Scarcity in energy sector is a major problem, which can hamper the growing development of a country. Bangladesh is one of the electricity-deprived countries; however, the energy demand of Bangladesh is increasing day by day. Due to the shortage of natural resources and environmental issues, many nations are now moving towards renewable energy. Among various form of renewable energy, wind energy...

According to recent simulations, the coalescence of two spinning black holes (BHs) could lead to a BH remnant with recoil speeds of up to thousands of km s(-1). Here we examine the circumstances resulting from a gas-rich galaxy merger under which the ejected BH would carry an accretion disk and be observable. As the initial BH binary emits gravitational radiation and its orbit tightens, a hole ...

We analyze ultrafast surface plasmon-polariton pulse reshaping effects and nonlinear propagation modes for metal/dielectric plasmon waveguides. It is found that group velocity and loss dispersion effects can substantially modify both pulse duration (broadening/narrowing) and intensity decay (acceleration/retardation) by as much as several tens of percentage points in the short-pulse regime and ...

In the “Western” cultures of business and science, there is an interesting and arguably irrational belief that quantitative measures are in all cases superior to qualitative measures. The consequences of this belief are more than an epistemological curiosity; the resulting over-reliance on quantitative measurement and undervaluation of qualitative reasoning can be measured in the tens of millio...

We describe a method to fabricate, transfer and validate via image processing nanofibre-based, unique security marks ('nanotags') for anti-counterfeiting purposes. Epitaxial surface growth of oligophenylenes on a heated muscovite mica crystal results in a thin film of mutually aligned nanofibres with dimensions of tens of nanometres in height, hundreds of nanometres in width and tens to hundred...