Objective: Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. 18 β-Glycyrrhitic acid (GA) is chemically pentacyclic triterpenoid which possess powerful antiinflammatory action. The present study was designed to formulate GA reservoir-type transdermal patches using piperine as bioenhancer. Method: Transdermal Patch of GA was prepared...

Improving drug permeability in skin is considered as one of the most important issues for designing new methods of transdermal drug delivery. Consequently, many techniques have been proposed to more effectively deliver drugs across the stratum corneum, including chemical enhancers or physical enhancer techniques, e.g., iontophoresis and ultrasound. Standard hypodermic injection is an effective ...

Evidence There are no long-term RCTs, which leaves cohort and case-control studies as evidence. • The Society of Obstetricians and Gynaecologists of Canada1 and others2 have stated that evidence about the risk of VTE with different progestins is inconclusive owing to mixed results and a high risk of bias. • Some studies found no increased VTE risk with drospirenone3 or a transdermal patch.4 • S...

The aim of the study was to formulate and evaluate topically applied ketoprofen gels and patches and to see the effect of naturally occurring almond oil as penetration enhancer on the penetration of ketoprofen through artificial membrane/rabbit skin. Prior to ketoprofen gel and patch formulation, the particle size and particle size determination of ketoprofen was analyzed by Particle size analy...

OBJECTIVE To assess whether intermittent transdermal treatment with glyceryl trinitrate causes clinically significant rebound in patients maintained on beta blockers for stable angina pectoris. DESIGN Serial treadmill exercise testing in a double blind, randomised, placebo controlled cross over trial. Baseline exercise testing was performed at 0900 and 1100 at visit 1. Transdermal glyceryl tr...