Concepts rooted in physics are becoming increasingly important in biology as we transition to an era in which quantitative descriptions of all processes from molecular to cellular level are needed. In this perspective I discuss two unexpected findings of universal behavior, uncommon in biology, in the self-assembly of proteins and RNA. These findings, which are surprising, reveal that physics i...

Both the theory and practice of public interest lawyering are in transition. Whereas the public interest lawyer of the 1960s and 1970s typically advocated before administrative agencies and courts on behalf of poor people and underrepresented groups, the public interest lawyer of today assumes a much greater variety of roles and is involved in a broader array of tasks. One of the causes of this...

The era of programming with single processors has ended. Decades of prophesies have at last come true: programming with multiple processors has now entered the mainstream. Two forces have caused this transition to happen now. First, the Internet, which is a network of many loosely coupled processors. It had been gaining relevance for many years, but only recently has it achieved sufficient band...

A cosmology with a dynamical Planck mass mpl is shown to solve the horizon and monopole problems (and possibly flatness) if there is an early MAD (modified aging) era where the universe becomes older than in the standard model as a result of a large mpl: the causality condition is mpl(Tc)/mpl(To) ∼ Tc/To (Tc is some high temperature while To = 2.74K.) Unlike inflation, there is no period of vac...

BACKGROUND We present here the case of a patient with pulmonary arterial hypertension and NYHA Class II symptoms who transitioned from PDE-5i therapy to riociguat. No protocol currently exists for transitioning between these PAH medications. CASE PRESENTATION A 59-year old male with a history of anorexigen use initially presented in 2008 and was felt to have non-operable small vessel disease....

An overview on the present observational status and phenomenological understanding of cosmic rays above 10 eV is given. Above these energies the cosmic ray flux is expected to be gradually dominated by an extra-galactic component. In order to investigate the nature of this transition, current experimental activities focus on the measurement of the cosmic ray flux and composition at the ’ankle’ ...

Toy models for the Hubble rate or the scalar eld potential have been used to analyze the ampli-cation of scalar perturbations through a smooth transition from innation to the radiation era. We use a Hubble rate that arises consistently from a decaying vacuum cosmology, which evolves smoothly from nearly de Sitter innation to radiation domination. We nd exact solutions for super-horizon perturba...

The mouse is an ideal model system for studying the molecular mechanisms underlying the pathogenesis of human cancer. The generation of transgenic and gene-knockout mice has been instrumental in determining the role of major determinants in this process, such as oncogenes and tumor-suppressor genes. In the past few years, modeling cancer in the mouse has increased in its complexity, allowing in...

The concept of customer relationship management (CRM) resonates with managers in today's competitive economy. As more and more organizations realize the significance of becoming customer-centric in today's competitive era, they embrace CRM as a core business strategy. CRM an integration of information technology and relationship marketing provides the infrastructure that facilitates long-term r...

Despite advances in molecular characterization and lung cancer treatment in recent years, treatment options for patients diagnosed with squamous cell carcinoma of the lung (SCC) remain limited as actionable mutations are rarely detected in this subtype. This article reviews potential molecular targets and associated novel agents for the treatment of advanced SCC in the era of personalized medic...